A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.
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http://dx.doi.org/10.1016/s0960-894x(02)00601-7 | DOI Listing |
Spectrochim Acta A Mol Biomol Spectrosc
February 2025
The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel; Department of Materials Science and Engineering, The Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 6997801, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address:
Fluorescent chemosensors are highly important for various applications including medical diagnostics, environmental monitoring, and industrial processing. Significant advancements have been made to produce sensors capable of detecting biologically and environmentally relevant ions. Specifically, carbazole-derived fluorophores are chemically stable agents with the ability to detect anions, cations, and small bioorganic molecules.
View Article and Find Full Text PDFInt J Biol Macromol
November 2024
Department of Chemistry, Lorestan University, Khorram Abad, Lorestan, Iran.
In this study, a novel green poly(amino amide) nanoparticle based on cellulose nanoparticles (Cell-PAMN) was developed for the efficient adsorption of Congo Red dye. Cellulose nanocrystals obtained from acid hydrolysis of cotton linter were functionalized via Oxa-Michael addition of acrylamide on their surface hydroxyl groups, followed by transamidation with ethylenediamine. The resulting nanoparticles were characterized using FT-IR spectroscopy, SEM, and X-ray diffraction techniques.
View Article and Find Full Text PDFJ Hazard Mater
October 2024
College of Environment, Zhejiang University of Technology, Hangzhou 310032, PR China. Electronic address:
J Med Chem
August 2024
School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, P.R. China.
SHP2 plays a critical role in modulating tumor growth and PD-1-related signaling pathway, thereby serving as an attractive antitumor target. To date, no antitumor drugs targeting SHP2 have been approved, and hence, the search of SHP2 inhibitors with new chemical scaffolds is urgently needed. Herein, we developed a novel SHP2 allosteric inhibitor SDUY038 with a furanyl amide scaffold, demonstrating potent binding affinity ( = 0.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
October 2024
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, 610064, China.
Benzophenone skeletons containing a carbonyl unit (O=C) have been widely used as electron acceptors in the thermally activated delayed fluorescence (TADF) materials. Herein, we present a novel molecular design concept for TADF materials by transitioning from a carbonyl to an amide (O=C-N) skeleton as the acceptor. The amide unit, compared to its carbonyl counterpart, offers a more stable electronic configuration.
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