Background: Clinical observation has shown that many asthma-affected children and their parents are not familiar with appropriate techniques for inhaler use. This may result in misuse, overdose, or diminished response of the administered therapeutic drugs, or may even result in unnecessary, repeated hospitalization. Inappropriate inhalation technique is hazardous to the safety of children with asthma and unnecessarily increases costs resulting from unnecessary rehospitalization.
Objective: We designed a study to evaluate the skills needed for inhaler use among children with asthma in Taiwan.
Subjects And Methods: Schoolchildren with asthma, aged 8 to 13 years, were asked to demonstrate their inhalation technique. The inhalers used in this study were either metered-dose inhalers or dry-power inhalers. Assessment of the inhalation technique was made using a standardized inhaler checklist. A higher score indicates greater skill using the inhaler.
Results: This study surveyed 132 schoolchildren with asthma. Of those, only 23 (17.4%) asthmatic children who received inhalation therapy revealed good compliance with their medication regimens. No child was observed to have completed all inhaler techniques correctly. Those family members who participated in educational programs and who received instruction from health teams had higher scores for the inhaler checklist (P < 0.05). It was found that children who inhaled medication unaided had a better knowledge of asthma, and their drug inhalation technique was also more skillful (P < 0.03). By multiple regression analysis, we found that determinants of a child's skill at performing the inhalation maneuver included: number of asthma attacks within the preceding year, unaided application of inhaler therapy, older subject age, potential for subjects to receive instructions from parents regarding inhaler use, subjects reading related publications, and the family's degree of satisfaction with the physician's educational program. These variables contributed a total of 23% to variance in the subjects' inhalation technique.
Conclusion: This study revealed that most asthmatic children being treated with inhaler medication do not use such devices appropriately. More aggressive asthma education is necessary in Taiwan.
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http://dx.doi.org/10.1016/S1081-1206(10)61960-6 | DOI Listing |
AAPS J
January 2025
Laboratory of Pharmaceutical Technology and Biopharmacy, CIRM, University of Liège, 4000, Liège, Belgium.
In addition to the known therapeutic indications for cannabidiol, its administration by inhalation appears to be of great interest. Indeed, there is evidence of cannabidiol's efficacy in several physiological pathways, suggesting its potential for a wide range of applications for both local and systemic pulmonary administration like cancers. Significant advances in pulmonary drug delivery have led to innovative strategies to address the challenges of increasing the respirable fraction of drugs and standardizing inhalable products.
View Article and Find Full Text PDFAm J Physiol Lung Cell Mol Physiol
January 2025
Research Institute of the, McGill University Health Centre, Montreal, QC, Canada.
The increasing shift from cannabis smoking to cannabis vaping is largely driven by the perception that vaping to form an aerosol represents a safer alternative to smoking and is a form of consumption appealing to youth. Herein, we compared the chemical composition and receptor-mediated activity of cannabis smoke extract (CaSE) to cannabis vaping extract (CaVE) along with the biological response in human bronchial epithelial cells. Chemical analysis using HPLC and GC/MS revealed that cannabis vaping aerosol contained fewer toxicants than smoke; CaSE and CaVE contained teratogens, carcinogens, and respiratory toxicants.
View Article and Find Full Text PDFTransl Pediatr
December 2024
Central Laboratory, Jiangxi Provincial Children's Hospital, The Affiliated Children's Hospital of Nanchang Medical College, Nanchang, China.
Background: Oral microbiome homeostasis is important for children's health, and microbial community is affected by anesthetics. The application of anesthetics in children's oral therapy has become a relatively mature method. This study aims to investigate the effect of different anesthesia techniques on children's oral microbiota.
View Article and Find Full Text PDFCureus
December 2024
Department of Radiological Technology, Fujieda Municipal General Hospital, Fujieda, JPN.
Purpose This study aimed to clarify which positions are beneficial for patients with pathological lung diseases, such as acute respiratory distress syndrome, by obtaining lung ventilation and deformable vector field (DVF) images using Deformable Image Registration (DIR). Methods Thirteen healthy volunteers (5 female, 8 male) provided informed consent to participate to observe changes in normal lungs. DIR imaging was processed using the B-spline algorithm to obtain BH-CTVI (inhale, exhale) in four body positions (supine, prone, right lateral, left lateral) using DIR-based breath-hold CT ventilation imaging (BH-CTVI).
View Article and Find Full Text PDFUndersea Hyperb Med
January 2025
Department of Hyperbaric Oxygen, Changhai Hospital, Naval Medical University, 168 Changhai Rd, Shanghai, 200433, China.
Objective: To investigate the effect of 6 ATA air/ oxygen treatment scheme and 2.8 ATA oxygen inhalation scheme on cerebral gas embolism.
Methods: 29 patients with cerebral gas embolism admitted from January 2014 to June 2022 were retrospectively included.
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