AI Article Synopsis
- - An experiment on CD-1 mice showed that simvastatin combined with a high cholesterol diet and ethanol led to significant increases in fatty liver and elevated serum triacylglycerol levels.
- - The treated mice had liver lipid and cholesterol levels significantly higher than control mice, indicating the harmful effects of the treatment regimen.
- - When Arthrospira maxima algae was added to the diet before induction of fatty liver, it showed a protective effect by reducing liver and serum triacylglycerol levels and increasing beneficial HDL levels, though the exact mechanism wasn't identified.
Article Abstract
An evident fatty liver, corroborated morphologically and chemically, was produced in CD-1 mice after five daily doses of simvastatin 75 mg/Kg body weight, a hypercholesterolemic diet and 20 percent ethanol in the drinking water. After treating the animals, they presented serum triacylglycerols levels five times higher than the control mice, total lipids, cholesterol and triacylglycerols in the liver were 2, 2 and 1.5 times higher, respectively, than in control animals. When Arthrospira maxima was given with diet two weeks prior the onset of fatty liver induction, there was a decrement of liver total lipids (40%), liver triacylglycerols (50%) and serum triacylglycerols (50%) compared to the animals with the same treatment but without Arthrospira maxima. In addition to the mentioned protective effect, the administration of this algae, produced a significant increase (45%) in serum high density lipoproteins. The mechanism for this protective effect was not established in these experiments.
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| http://dx.doi.org/10.1016/s0024-3205(02)01512-6 | DOI Listing |
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