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Article Synopsis
  • Uremic leontiasis ossia (ULO) is a rare condition linked to renal osteodystrophy in patients with end-stage chronic kidney disease (CKD) and secondary hyperparathyroidism (SHPTH), causing bone deformities that can lead to a 'leonine' facial appearance.
  • The case study focuses on a 39-year-old female patient undergoing treatment, who exhibited significant symptoms and had elevated parathyroid hormone (PTH) levels, confirmed by CT scans.
  • Treatment involves a multidisciplinary approach including surgery and management of SHPTH to correct anatomical issues and prevent further complications.
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Background Calcific uremic arteriolopathy (CUA) is a rare but debilitating disease affecting patients with kidney disease. Reported risk factors of CUA in the literature include female sex, obesity, diabetes mellitus, and vitamin K antagonists' (VKAs) usage. CUA prevalence in Malaysia is unknown and has not been reported before.

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The Bone-Vascular Axis: A Key Player in Chronic Kidney Disease Associated Vascular Calcification.

Kidney Dis (Basel)

December 2024

Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Background: The bone-vascular axis plays a key role in the pathogenesis of vascular calcification (VC) in patients with chronic kidney disease (CKD). Understanding and managing the role of the bone-vascular axis in CKD-mineral and bone disorder (CKD-MBD) is critical for preventing and treating associated complications, including osteoporosis, arterial calcification, and cardiovascular diseases. This study aimed to comprehensively summarize the role of bone metabolism markers in uremic VC.

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Adiposity and Mineral Balance in Chronic Kidney Disease.

Curr Osteoporos Rep

December 2024

Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, 46202, USA.

Purpose Of Review: Bone homeostasis is balanced between formation and resorption activities and remain in relative equilibrium. Under disease states this process is disrupted, favoring more resorption over formation, leading to significant bone loss and fracture incidence. This aspect is a hallmark for patients with chronic kidney disease mineral and bone disorder (CKD-MBD) affecting a significant portion of the population, both in the United States and worldwide.

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Article Synopsis
  • Chronic Kidney Disease (CKD) leads to malnutrition and body composition changes, such as increased fat mass and decreased lean mass and bone mineral density, which persist even after a kidney transplant due to immunosuppressive therapy.
  • A study comparing body composition among kidney transplant patients, hemodialysis patients, and a healthy control group revealed that kidney transplant patients had lower lean mass and bone mineral density compared to controls, indicating incomplete recovery post-transplant.
  • The findings highlight that despite expectations for improved body composition after a kidney transplant, patients still fall short of "normal" values observed in healthy individuals of similar age.
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