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Proton Versus CyberKnife Therapy Planning for Hypofractionated Treatment of Prostate With Focal Boost.
Int J Part Ther
December 2024
Department of Advanced Radiation and Proton Therapy, INOVA Schar Cancer Institute, Fairfax, VA, USA.
Purpose: To compare intensity-modulated proton therapy with CyberKnife (CK) therapy for hypo-fractionated treatments of prostate with focal boost, as a first planning study for prostate with dose escalation to a dominant intraprostatic lesion (DIL).
Materials And Methods: Ten patients who possess one DIL in their prostate and their CK plans that were used to treat the planning target volume of prostate were chosen. Six of the plans were further escalated to DIL.
Safety of non-invasive brain stimulation in patients with implants: a computational risk assessment.
J Neural Eng
November 2024
Foundation for Research on Information Technologies in Society (IT'IS), Zeughausstrasse 43, Zurich, 8004, SWITZERLAND.
Objective: Non-invasive brain stimulation (NIBS) methodologies, such as transcranial electric (tES) are increasingly employed for therapeutic, diagnostic, or research purposes. The concurrent presence of active/passive implants can pose safety risks, affect the NIBS delivery, or generate confounding signals. A systematic investigation is required to understand the interaction mechanisms, quantify exposure, assess risks, and establish guidance for NIBS applications.
View Article and Find Full Text PDFDosimetric optimization for dynamic mixed beam arc therapy (DYMBARC).
Med Phys
January 2025
Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Background: Non-coplanarity and mixed beam modality could be combined to further enhance dosimetric treatment plan quality. We introduce dynamic mixed beam arc therapy (DYMBARC) as an innovative technique that combines non-coplanar photon and electron arcs, dynamic gantry and collimator rotations, and intensity modulation with photon multileaf collimator (MLC). However, finding favorable beam directions for DYMBARC is challenging due to the large solution space, machine component constraints, and optimization parameters, posing a highly non-convex optimization problem.
View Article and Find Full Text PDFLarge-field irradiation techniques in Germany: A DGMP Working Group survey on the current clinical implementation of total body irradiation, total skin irradiation and craniospinal irradiation.
Z Med Phys
October 2024
Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany.
In 2023, a Germany-wide survey on the current clinical practice of three different large field irradiation techniques (LFIT), namely total body irradiation (TBI), total skin irradiation (TSI) and craniospinal irradiation (CSI), was conducted covering different aspects of the irradiation process, e.g., the irradiation unit and technique, dosimetrical aspects and treatment planning as well as quality assurance.
View Article and Find Full Text PDFHybrid modality dual-energy imaging aggregating complementary advantages of kV-CT and MV-CBCT: concept proposal and clinical validation.
Phys Med Biol
October 2024
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing Cancer Hospital & Institute, Beijing, China, 38 Xueyuan Rd , Haidian District,Beijing,China, Beijing, 100142, CHINA.
Article Synopsis
- Megavoltage cone-beam CT (MV-CBCT) helps reduce metal artifacts in radiation therapy but struggles with soft tissue contrast; a new dual-energy imaging method combining kV-CT and MV-CBCT aims to address these issues.
- This method involves acquiring images from both technologies, creating basis material images, and quantitatively analyzing their accuracy using a specific phantom.
- Results showed significant improvements in soft tissue contrast and reduced metal artifacts, with errors in soft-tissue red color (RED) dropping drastically, demonstrating that this technique could enhance the effectiveness of image-guided radiotherapy without needing new hardware or additional doses.
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