The authors have studied the RCD spread in Vratza district according to the material of the therapeutic departments in the district for the period 1969--1973 and according to the material of the out-patient department -- polyclinical--1971--1973. During that period 16,294 patients with diseases of the urinary system were registered, 6311 out of them with RCD, i. e. 38.7 per cent. The region of Mezdra was established to be the highest affected by RCD in the district (60,8%), followed by Belaslatina region (43.4%), Vratza (40%), Kneza (37.9%) and Orejahovo the last--(22.4%). Females were established to suffer more frequently (56.7%) as compared with males (43.3%) and the peasants 51.8%) insignificantly more often in comparison with the the townsmen (48.7%). All ages are affected by the disease but most frequently the individuals aged 31--50 (49.5%). Workers (36.4%) are those that most frquently suffer of RCD in the district of Vratza, followed by employees (23.4%), cooperative farmers (21.6%), etc. The authors have established that renal calculosis affects most frequently the right kidney (56.6%) as compared with the left (40.4%) and very rarely both kidneys (2.94).
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Front Med (Lausanne)
October 2024
School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China.
Ferroptosis is a type of regulated cell death that occurs due to the iron-dependent accumulation of lethal reactive oxygen species (ROS) from lipids. Ferroptosis is characterized by distinct morphological, biochemical, and genetic features that differentiate it from other regulated cell death (RCD) types, which include apoptosis, various necrosis types, and autophagy. Recent reports show that ferritin formation is correlated to many disorders, such as acute injury, infarction, inflammation, and cancer.
View Article and Find Full Text PDFBiochim Biophys Acta Rev Cancer
November 2024
Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Guangdong Medical University, Shenzhen 518110, China. Electronic address:
Copper, a vital micronutrient, performs essential functions in numerous biological settings. Its disrupted metabolism is implicated in both the initiation of tumors and therapeutic interventions for cancer, underscoring the critical necessity of preserving copper homeostasis. Cuproptosis, a regulated cell death (RCD) modulated by copper, is activated in response to elevated copper concentrations, prompting an investigation into its implication in oncogenesis.
View Article and Find Full Text PDFCell Mol Biol Lett
May 2024
Translational Medicine Research Center, Medical Innovation Research Division of the Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Studies have indicated that immune dysfunction plays a central role in the pathogenesis of sepsis. Dendritic cells (DCs) play a crucial role in the emergence of immune dysfunction in sepsis.
View Article and Find Full Text PDFiScience
June 2024
Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Non-apoptotic regulated cell death (RCD) of tumor cells profoundly affects tumor progression and plays critical roles in determining response to immune checkpoint inhibitors (ICIs). Prognosis-distinctive HCC subtypes were identified by consensus cluster analysis based on the expressions of 507 non-apoptotic RCD genes obtained from databases and literature. Meanwhile, a set of bioinformatic tools was integrated to analyze the differences of the tumor immune microenvironment infiltration, genetic mutation, copy number variation, and epigenetics alternations within two subtypes.
View Article and Find Full Text PDFAutoimmunity
December 2023
Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Background: In order to better understand the interplay between ferroptosis and autophagy, enhance the interpretation of the crosstalk between these two forms of regulated cell death, develop the effective pharmacological mechanisms for cancer treatment, discover novel biomarkers for better diagnostic, and envisage the future hotspots of the research on ferroptosis and autophagy, we harnessed bibliometric tools to study the articles published from 2012 to 2022 on the relationship between ferroptosis and autophagy.
Methods: Web of Science Core Collection (WOSCC) database was used to conduct a comprehensive search and analysis of articles in this field from January 1, 2012, to September 1, 2022. The Citespace 6.
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