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The application value of dynamic electroencephalography combined with brainstem auditory evoked potential in evaluating the degree of vascular stenosis and prognosis in patients with ischemic stroke: A retrospective analysis.
Medicine (Baltimore)
January 2025
Department of Neurology and Geriatrics, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, China.
The aim was to explore the application value of dynamic electroencephalography (EEG) combined with brainstem auditory evoked potential (BAEP) in evaluating the degree of vascular stenosis and prognosis in patients with ischemic stroke (IS). This was a retrospective study using clinical data of patients with IS admitted to the First Affiliated Hospital of Chongqing Medical and Pharmaceutical College from March 2020 to March 2022. The degree of vascular stenosis and prognosis of patients were analyzed.
View Article and Find Full Text PDFIridium-Catalyzed Highly Selective 1,4-Reduction of α,β-Unsaturated Carbonyl Compounds.
Molecules
December 2024
Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.
In this study, an iridium-catalyzed selective 1,4-reduction of α,β-unsaturated carbonyl compounds is realized, with water as a solvent and formic acid as a hydride donor. The new efficient iridium catalyst features a 2-(4,5-dihydroimidazol-2-yl)quinoline ligand. The chemoselectivity and catalyst efficiency are highly dependent on the electronic and steric properties of the substrates.
View Article and Find Full Text PDFMethodology and Experimental Protocol for Fatigue Analysis in Suggestopedia Teachers.
Brain Sci
November 2024
Institute of Robotics, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., 1113 Sofia, Bulgaria.
Background: Among all professions, teaching is significantly affected by psycho-social risks with approximately 33.33% of educators reporting work-related fatigue. Suggestopedia, an effective pedagogical approach developed in Bulgaria, claims to induce positive psychological and cognitive benefits in both teachers and students.
View Article and Find Full Text PDFNormal tissue complication probability modeling for late rectal bleeding after conventional or hypofractionated radiotherapy for prostate cancer.
Clin Transl Radiat Oncol
January 2025
Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
Article Synopsis
- The study aimed to create a predictive model for late rectal bleeding in prostate cancer patients undergoing different types of radiotherapy.
- Candidate predictors were identified from prior research and five logistic regression models were tested based on various dose parameters.
- Results indicated that certain dosimetric predictors and history of abdominal surgery were significant for predicting the outcome, with some models showing satisfactory internal validation, but external validation is necessary for confirmation.
Chemical O-ADP-Ribosylations: Synthesis and Bioconjugation of ADPr-Peptides/Proteins from NAD.
Angew Chem Int Ed Engl
January 2025
Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, State Key Laboratory of Antiviral Drug and Pingyuan Lab, Henan Normal University, Xinxiang, Henan, 453007, China.
ADP-ribosylation is a complex post-translational modification involved in key physiological processes and associated with various health and disease states. The growing interest in ADP-ribosylation necessitates straightforward and efficient synthetic methods for the preparation of ADP-ribosylated peptides/proteins. In this study, we report a facile reaction between nicotinamide adenine dinucleotide (NAD) and alcohols promoted by a combination of ionic liquids, yielding up to 94 % with α : β ratios ranging from 88 : 12 to 99 : 1 and a switchable configuration selectivity.
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