AI Article Synopsis
- A study examined 50 asymptomatic HBV carriers (25 males, 25 females) over an average follow-up of 15.5 years, focusing on the distribution of HBV genotypes.
- Genotype B was found in 54% of the subjects, which is notably higher compared to genotype C, challenging previous findings that linked genotype C with chronic liver issues.
- Results indicated that genotype B carriers had better clinical stability, lower HBV-DNA levels, and a higher seroconversion rate from HBeAg to anti-HBe than genotype C carriers, who faced a higher risk of chronic liver disease particularly in those aged 40 and older.
Article Abstract
Randomly selected 50 asymptomatic hepatitis B virus (HBV) carrier residents who had been followed annually were enrolled in this study. The subject group comprised 25 males and 25 females with a mean age at the start of follow-up of 44.1+/-10.4 years. The mean follow-up period was 15.5+/-2.7 years. Genotyping revealed 27 (54%) of genotype B and 23 (46%) of genotype C. The prevalence of genotype B was clearly higher in asymptomatic HBV carrier redidents, which was contrary to the previous reports on chronic liver disease. At the start of follow-up, the ratio of carriers positive for anti-HBe was significantly higher in genotype B than genotype C (P<0.001). Furthermore, the ratio of carriers with reduced HBV-DNA levels was significantly higher in genotype B than genotype C (P<0.01), suggesting that most genotype B carriers had already undergone seroconversion from HBeAg to anti-HBe and were clinically stable at the start of follow-up. The subsequent follow-up observations demonstrated that levels of HBV-DNA and ALT were lower in genotype B than genotype C. Seroconversion from HBeAg to anti-HBe was less likely to occur in genotype C carriers, especially on 40-year-old generation, and these subjects were more likely to develop chronic liver disease.
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| http://dx.doi.org/10.1016/s1386-6346(02)00017-7 | DOI Listing |
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