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Multimodal genome-wide survey of progressing and non-progressing breast ductal carcinoma in-situ.
Breast Cancer Res
December 2024
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Article Synopsis
- Ductal carcinoma in-situ (DCIS) is a non-invasive breast cancer type that makes up about 25% of breast cancer cases, but it often leads to unnecessary aggressive treatment despite many cases never progressing to invasive cancer.
- A study analyzed 197 breast tissue samples to explore molecular changes in DCIS, using techniques like mRNA expression and DNA analysis to compare progressing versus non-progressing cases.
- The research found significant molecular differences among DCIS subtypes and between DCIS and invasive breast cancer, highlighting the complexity of DCIS and the need for more tailored approaches to assess risk and treatment.
Immunological and molecular features of the tumor microenvironment of long-term survivors of ovarian cancer.
J Clin Invest
October 2024
School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
BACKGROUNDDespite an overall poor prognosis, about 15% of patients with advanced-stage tubo-ovarian high-grade serous carcinoma (HGSC) survive 10 or more years after standard treatment.METHODSWe evaluated the tumor microenvironment of this exceptional, understudied group using a large international cohort enriched for long-term survivors (LTS; 10+ years; n = 374) compared with mid-term (MTS; 5-7.99 years; n = 433) and short-term survivors (STS; 2-4.
View Article and Find Full Text PDFThe Lancet Psychiatry Commission on mental health in Ukraine.
Lancet Psychiatry
November 2024
Regional Centre for Child and Youth Mental Health and Child Welfare, Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Plasma Ghrelin and Risks of Sex-Specific, Site-Specific, and Early-Onset Colorectal Cancer: A Mendelian Randomization Analysis.
Cancer Epidemiol Biomarkers Prev
December 2024
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
Article Synopsis
- - The study investigated the potential link between ghrelin, a hormone, and colorectal cancer using a two-sample Mendelian randomization approach, analyzing data from over 54,000 participants.
- - Results showed no significant association between genetically predicted plasma ghrelin levels and colorectal cancer risk, even when considering factors like sex, cancer subsite, and age at diagnosis.
- - The findings contribute to the existing evidence suggesting that plasma ghrelin levels do not play a causal role in the development of colorectal cancer.
Red Blood Cell Transfusion in Critically Ill Adults: An American College of Chest Physicians Clinical Practice Guideline.
Chest
September 2024
Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, MI.
Article Synopsis
- Blood products, specifically RBC transfusions, are commonly used in critically ill patients, prompting a detailed review of current practices and evidence to guide healthcare providers.
- A panel of experts evaluated existing literature and developed specific questions regarding RBC transfusions, ultimately analyzing 23 key studies to form strong and conditional recommendations.
- Overall, a restrictive transfusion strategy was found to be safer for most critically ill patients, decreasing RBC use without raising the risk of death or complications; however, it may not be suitable for patients with acute coronary syndrome (ACS).
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