AI Article Synopsis

  • Progesterone (10 mg) injected into estrogen-primed women stimulates the release of prolactin and gonadotropin simultaneously.
  • The release of these hormones follows a 4-hour delay and continues for at least 5 hours.
  • This hormonal response is thought to occur due to progesterone decreasing the levels of hypothalamic dopamine.

Article Abstract

Progesterone (10 mg) administered intramuscularly induces a concurrent release of prolactin as well as gonadotropin in estrogen-primed women. The time course of pituitary release of all three of these hormones appears to include a latent phase of 4 hrs and is maintained for at least 5 hrs. It is considered that this effect of progesterone may be mediated through a reduction of hypothalamic dopamine.

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http://dx.doi.org/10.1210/jcem-47-4-918DOI Listing

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