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Therapeutic effect of sinestrol was investigated in 15 patients with progressive muscular dystrophy of Duchenne (PMDD) aged 7 to 10 years, at stage II of the disease. The drug was given orally 1 mg twice a day for 3 weeks. Control group consisted of 14 patients with PMDD aged 7 to 9 years.

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Clinical and electrophysiological examinations of 24 patients with myotonia (Thomsen's myotonia--10 patients and myotonic dystrophy--14 patients) ascertained criteria of the general and differential diagnosis of myotonia. Apart from electromyographic changes the patients presented a considerable decrease in the speed of afferent and efferent conduction of impulses along peripheral nerves in myotonic dystrophy, which justifies the inclusion into combined therapy of means improving conduction along nerve fibers.

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