OxyContin (oxycodone hydrochloride controlled release) is a long-acting preparation of oxycodone that is used as an opioid analgesic to treat chronic pain conditions. We report a patient who ingested a massive quantity of OxyContin and had altered mental status, noncardiogenic pulmonary edema, and hypoventilation that proved refractory to naloxone administration. She required mechanical ventilation for 3 days before recovering completely. The severity and length of poisoning was likely related both to the quantity and formulation of the oxycodone ingested.
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http://dx.doi.org/10.1067/mem.2002.128143 | DOI Listing |
Heliyon
July 2024
Department of Pharmacy, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, 278 Baoguang Street, Xindu District Chengdu, 610500, Sichuan, China.
Behav Pharmacol
August 2024
Refractories, Ceramics and Building Materials Department, Advanced Materials, Technology and Mineral Resources Research Institute, National Research Centre (NRC), Giza, Egypt.
Drug dependence is a chronic brain disease characterized by craving and recurrent episodes of relapse. Tramadol HCl is a promising agent for withdrawal symptoms management, considering its relatively low abuse potential and safety. Oral administration, however, is not preferred in abstinence maintenance programs.
View Article and Find Full Text PDFSubst Abuse Treat Prev Policy
February 2024
Denver Health & Hospital Authority, 777 Bannock St, 80204, Denver, CO, USA.
Background: Combinations of alcohol use disorder (AUD) medications have been investigated, but few if any reports describe patients maintained on more than two options at the same time.
Case Presentation: We report a case of a middle-aged man hospitalized with gastrointestinal bleeding and acute kidney injury who had been maintained on four AUD medications (naltrexone, acamprosate, disulfiram, and gabapentin) and multiple psychiatric medications simultaneously as an outpatient. Direct quotations of his experiences with each AUD medication are included, revealing some deviations from what was prescribed as well as nuanced perceptions of effects.
Fundam Clin Pharmacol
June 2024
Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Background/objectives: Clinical responses to naldemedine vary between individuals with advanced cancer. This is a prospective, single-center, observational study aimed to evaluate the influence of genetic polymorphisms and cachexia status on plasma naldemedine and clinical responses.
Methods: Forty-eight patients being treated with naldemedine for opioid-induced constipation under treatment of cancer pain were enrolled.
Int J Pharm Compd
December 2023
Professional Compounding Centers of America, Houston, Texas.
Naltrexone is a competitive opioid receptor antagonist indicated to treat opioid and alcohol dependence. In the U.S.
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