[Lipid peroxidation in the rats striatum during stress after cortisol administration].

Lipid peroxidation in the rat striatum under stress after cortisole injection was investigated. Three days cortisole injections (25 mg/kg every day) do not affect the level of lipid peroxidation products 6 days after termination of the hormone injection. However, in these periods, cortisole injected rats had a more significant response of lipid peroxidation to stress than the control animals (decrease of intermediate products and increase of Shift bases). Thus, the hormone injection induced a long-term changes in so important a regulatory system of the organisms as the lipid peroxidation, causing sensitization of its response to stress.