Background: Incidence of tuberculosis (TB) in the Czech Republic (CR) during the year 2000 was evaluated on the basis of newly detected cases as well the restriction of known TB sources by antituberculosis treatment. Data from compulsory reported TB cases in the TB register for the year 2000 were used as well as data from the analysis of treatment in cohorts of patients reported quarterly in 1999 and evaluated 12 months later.
Methods And Results: 1442 cases of new diseases and TB relapses were reported in 2000 (14.1/100,00). 1244 cases (12.1/100,000) were TB of the respiratory system, 198 cases (2.0/100,000) belonged to the extra-respiratory TB. 61.9% of cases were bacteriologically verified TB of the respiratory system. In comparison with the year 1999, the number of TB cases was lower by 11.7%, respectively by 9.3% in TB of the respiratory system. The positive trend in TB incidence recorded in CR since 1998 has continued. From 1442 cases of the TB, 916 were males (63.5%) and 526 females (36.5%). Majority of patients was older than 65 years. 143 (9.9%) of TB cases were patients born extra CR ("foreigners"), namely coming from Ukraine (41), Vietnam (16), and Romania (14). 74 patients died of tuberculosis, mostly those older than 65 years. The youngest was the 24-year-old Ukrainian and a 38 year old homeless person, the citizen of CR. The highest incidence of TB was in West Bohemia, in Prague and in North Moravia; the lowest incidence was in South Moravia and in South Bohemia. TB was identified because of patient's troubles (68.0%), in the risk groups (13.3%), and by examination of contact persons (4.7%). Other mycobacteriosis than TB was identified in 92 patients. The treatment was evaluated in 606 persons with the pulmonary TB, which was bacteriologically verified; analysis was done in cohorts of patients reported quarterly in 1999. 70.1 to 77.5% of patients in individual cohorts were successfully treated, in 3 patients the treatment failed and 9 patients interrupted the treatment. Remaining 25% of patients either died before or during the treatment. The high mortality rate resulted from the high age and other diseases in some of the patients.
Conclusions: WHO includes CR between countries with low TB incidence. Within the stabile population of CR the continuous decrease of TB incidence should continue, unless some unfavourable effects occur.
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Pediatr Infect Dis J
January 2025
Public Health Secretariat, Department of Health, Generalitat de Catalunya, Barcelona, Spain.
Background: In Catalonia, infants <6 months old were eligible to receive nirsevimab, a novel monoclonal antibody against respiratory syncytial virus (RSV). We aimed to analyze nirsevimab's effectiveness in hospital-related outcomes of the seasonal cohort (born during the RSV epidemic from October to January 2024) and compared them with the catch-up cohort (born from April to September 2023).
Methods: Retrospective cohort study of all infants born between October 1, 2023, and January 21, 2024, according to their immunization with nirsevimab (immunized and nonimmunized).
PLoS Pathog
January 2025
Graduate Program in Immunology, Ann Arbor, Michigan, United States of America.
Neutrophils play key protective roles in influenza infections, yet excessive neutrophilic inflammation is a hallmark of acute lung injury during severe infections. Phenotypic heterogeneity is increasingly recognized in neutrophil populations; however, how functional variation in neutrophils between individuals determine the diverse outcomes of influenza remains unclear. To examine immunologic responses that may drive varying outcomes in influenza, we infected C57BL/6 (B6) and A/J mice with mouse-adapted influenza A virus A/PR/8/34 H1N1.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China.
Despite substantial advances in the antitumor effects of annonaceous acetogenins (ACGs), the absence of a defined biological action mechanism remains a major barrier to their clinical application. Here, it is found that squamocin effectively depletes both EZH2 and MYC in multiple cancer cell lines, including head and neck squamous cell carcinoma, and gastric and colorectal cancer, demonstrating potent efficacy in suppressing these in vivo tumor models. Through the combination of surface plasmon resonance (SPR), differential scanning fluorimetry (DSF), and cellular thermal shift assay (CETSA), heat shock protein 90α (HSP90α) is identified as the direct binding target of squamocin.
View Article and Find Full Text PDFPLoS One
January 2025
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Introduction: Haemodynamic atrioventricular delay (AVD) optimisation has primarily focussed on signals that are not easy to acquire from a pacing system itself, such as invasive left ventricular catheterisation or arterial blood pressure (ABP). In this study, standard clinical central venous pressure (CVP) signals are tested as a potential alternative.
Methods: Sixteen patients with a temporary pacemaker after cardiac surgery were studied.
J Cell Mol Med
January 2025
Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
The pathogenesis of chronic thromboembolic pulmonary hypertension may be multifactorial and requires further studies. We explored alterations in pulmonary artery endothelial cells under the hypoxic and elevated interleukin-17 conditions that are commonly present in patients with chronic thromboembolic pulmonary hypertension. We measured the serum interleukin-17 levels in 10 chronic thromboembolic pulmonary hypertension patients and 10 healthy control persons.
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