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Twenty-six week carcinogenicity study of ampicillin in CB6F1-TgrasH2 mice. | LitMetric

AI Article Synopsis

  • A 26-week carcinogenicity study was conducted on ampicillin (ABPC) using Tg-rasH2 mice as part of the ILSI-HESI ACT program.
  • ABPC was administered at varying doses (0, 350, 1000, 3000 mg/kg) to Tg-rasH2 mice and (0, 3000 mg/kg) to Non-Tg mice, while a positive control (MNU) was given to evaluate tumor development.
  • The results indicated no increase in tumor development in Tg-rasH2 mice, suggesting that ampicillin does not exhibit carcinogenic properties in this study.

Article Abstract

As a part of the ILSI-HESI Alternative to Carcinogenicity Testing (ACT) program, we performed a 26-week carcinogenetic study of nonmutagenic drug, ampicillin (ABPC) in Tg-rasH2 mice. ABPC was given to Tg-rasH2 mice (0, 350, 1000, 3000 mg/kg, p.o.) and Non-Tg mice (0, 3000 mg/kg, p.o.) daily for 26 weeks. As a positive control, a single dose of MNU was administered once to Tg-rasH2 mice (75 mg/kg, i.p.). In this study, Tg-rasH2 mice did not demonstrate any increases in tumor development in response to ABPC. Thus, ABPC had no carcinogenicity in the 26-week carcinogenesis study in Tg-rasH2 mice or in a 2-year carcinogenesis study in B6C3F1 mice.

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Source
http://dx.doi.org/10.2131/jts.27.147DOI Listing

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