The antimicrobial and antifungal properties of several crude extracts and pure saponins, astraverrucins I-VI, from the aerial parts of Astragalus verrucosus were investigated by the disc diffusion method. Antimycotic activity was observed on more polar extracts, but only one saponin showed an appreciable activity.
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http://dx.doi.org/10.1016/s0367-326x(02)00087-4 | DOI Listing |
Nat Prod Res
January 2025
Department of Medical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Drone larvae (DL) has many biological activities thanks to the bioactive components it contains, but there are very few studies on its antimicrobial activity. The aim of this research was to determine the antifungal activity of DL (raw and lyophilised) water and ethanol extracts against fluconazole (FLU) sensitive and resistant yeast strains. The 87 fungal strains obtained from clinical samples were identified by phenotypic and molecular methods, and broth microdilution test was used for antifungal activity.
View Article and Find Full Text PDFFoods
December 2024
Department of Food Science, Université Laval, Québec, QC G1V 0A6, Canada.
Porcine blood, a significant byproduct of the pork industry, represents a potential source of antimicrobial peptides (AMPs). AMPs offer a promising alternative to chemical antimicrobials, which can be used as natural preservatives in the food industry. AMPs can exhibit both antibacterial and/or antifungal properties, thus improving food safety and addressing the growing concern of antibiotic and antifungal resistance.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Faculty of Chemistry and Pharmacy, University of Opole, Oleska 48, 45-052 Opole, Poland.
O-Methyldehydroserine, ΔSer(Me), is a non-standard α,β-dehydroamino acid, which occurs naturally in Cyrmenins with potential pharmaceutical application. The C-terminal part and the side chain of the ΔSer(Me) residue constitute the β-methoxyacrylate unit, responsible for antifungal activity of Cyrmenins. The short model, Ac-ΔSer(Me)-OMe, was analyzed considering the geometrical isomer Z () and E ().
View Article and Find Full Text PDFInt J Mol Sci
January 2025
College of Plant Protection, Henan Agricultural University, Zhengzhou 450046, China.
B-box (BBX) transcription factors play crucial roles in plant growth, development, and defense responses to biotic and abiotic stresses. In this study, we cloned a BBX transcription factor gene, from cucumber and analyzed its role in the plant's defense against the feeding of . is expressed throughout all developmental stages in cucumber, with the highest expression in the leaves.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72388, Saudi Arabia.
Eumycetoma, a chronic fungal infection caused by , is a neglected tropical disease characterized by tumor-like growths that can lead to permanent disability and deformities if untreated. Predominantly affecting regions in Africa, South America, and Asia, it imposes significant physical, social, and economic burdens. Current treatments, including antifungal drugs like itraconazole, often show variable efficacy, with severe cases necessitating surgical intervention or amputation.
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