Objective: The goal of this study was to determine the effectiveness of an endoscopic option for anterior approaches to the thoracolumbar spine for scoliosis treatment. Fifty patients with 24 to 45 months of follow-up data were retrospectively studied. Techniques for endoscopic treatment of spinal disorders have been under development since 1993. The benefits of thoracoscopic surgery for the treatment of spinal deformities have been documented as improved observation of the spine, enhanced access to the extremes of the curve, decreased operative times and blood losses, shorter hospital stays and recuperative periods, and decreased overall costs. After more than 150 endoscopic procedures for the treatment of these spinal deformities had been performed, the next step was to develop a thoracoscopic technique for instrumentation, correction, and fusion for the treatment of primary thoracic scoliosis. Our goal has been to develop a safe, reproducible, and effective endoscopic technique for the treatment of scoliosis that can provide equal or better outcomes, compared with formal open surgical techniques.
Methods: Between October 1996 and October 1998, 50 patients with a diagnosis of primary thoracic scoliosis were selected to undergo thoracoscopic instrumentation, correction, and fusion. Postoperatively, patients were assessed with respect to restoration of spinal alignment, axial derotation, pain management, and incidence of complications.
Results: Endoscopic instrumentation was successfully performed for all patients. Curve correction averaged 50.2%, improving to 68.6% in the last 10 cases. Patients with hypokyphosis averaged 20.7 degrees of correction. The preoperative axial rotation (as measured with a scoliometer) averaged 16 degrees, which was corrected to 5 degrees. Postoperative pain was less, and patients could discontinue the use of all pain medications by 1 to 3 weeks, compared with patients who underwent formal open procedures, who required pain medication for 6 to 12 weeks. The hospital stays averaged 2.9 days. Our initial complication rate was high, which could be attributed to the development of a new technique. Keys to successful fusions include total discectomy, complete endplate removal, and the use of autogenous bone graft.
Conclusion: Although these techniques are still in early development, the initial results for our thoracoscopic techniques are promising. With experience, surgical times are decreasing and fusion and curve correction rates are improving. With further evolution, patients should realize shortened hospitalizations, decreased rehabilitation times, and decreased levels of postoperative pain. This is a technically demanding procedure that requires demonstrated skills in endoscopic discectomy and fusion.
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http://dx.doi.org/10.1097/00006123-200210000-00023 | DOI Listing |
Curr Pain Headache Rep
January 2025
Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL, 60657, USA.
Purpose Of The Review: In the United States, spinal cord injuries affect approximately 18,000 individuals annually, most commonly resulting from mechanical trauma. The consequent paraplegia severely impairs motor functions, creating an urgent need for innovative therapeutic strategies that extend beyond traditional rehabilitation and pharmacotherapy. This review assesses the effectiveness of Spinal Cord Stimulation (SCS) in improving motor function in patients with spinal cord injuries, with a particular focus on paraplegia.
View Article and Find Full Text PDFNeuromolecular Med
January 2025
Department of Anatomy, School of Basic Medical Sciences, Shanxi Medical University, No 56, Xinjian Nan Road, Taiyuan, 030001, Shanxi, China.
The integrity of the myelin sheath of the spinal cord (SC) is essential for motor coordination. Seipin is an endoplasmic reticulum transmembrane protein highly expressed in adipose tissue and motor neurons in the SC. It was reported Seipin deficiency induced lipid dysregulation and neurobehavioral deficits, but the underlying mechanism, especially in SC, remains to be elucidated.
View Article and Find Full Text PDFElife
January 2025
Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, Canada.
Locomotion is controlled by spinal circuits that interact with supraspinal drives and sensory feedback from the limbs. These sensorimotor interactions are disrupted following spinal cord injury. The thoracic lateral hemisection represents an experimental model of an incomplete spinal cord injury, where connections between the brain and spinal cord are abolished on one side of the cord.
View Article and Find Full Text PDFAlzheimers Dement
January 2025
Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, New York, USA.
This proceedings article summarizes the inaugural "T Cells in the Brain" symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics included characterization of antigen-specific immune responses, T cell receptor (TCR) repertoire, microbial etiology in Alzheimer's disease (AD), and microglia-T cell crosstalk, with a focus on how T cells affect neuroinflammation and AD biomarkers like amyloid beta and tau.
View Article and Find Full Text PDFGlobal Spine J
January 2025
Swedish Neuroscience Institute, Department of Neurosurgery, Swedish Health Services, Seattle, WA, USA.
Study Design: Prospective Observational Propensity Score.
Objectives: Randomization may lead to bias when the treatment is unblinded and there is a strong patient preference for treatment arms (such as in spinal device trials). This report describes the rationale and methods utilized to develop a propensity score (PS) model for an investigational device exemption (IDE) trial (NCT03115983) to evaluate decompression and stabilization with an investigational dynamic sagittal tether (DST) vs decompression and Transforaminal Lumbar Interbody Fusion (TLIF) for patients with symptomatic grade I lumbar degenerative spondylolisthesis with spinal stenosis.
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