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Demographic-Based Personalized Left Ventricular Hypertrophy Thresholds for Hypertrophic Cardiomyopathy Diagnosis.
J Am Coll Cardiol
December 2024
Barts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Background: Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death. Current diagnosis emphasizes the detection of left ventricular hypertrophy (LVH) using a fixed threshold of ≥15-mm maximum wall thickness (MWT). This study proposes a method that considers individual demographics to adjust LVH thresholds as an alternative to a 1-size-fits-all approach.
View Article and Find Full Text PDFA Perspective on the MARS2 Trial.
J Thorac Oncol
January 2025
Department of Cardiothoracic Surgery, New York University Langone Health, New York, New York. Electronic address:
Introduction: The phase 3 randomized controlled trial of extended pleurectomy decortication and chemotherapy versus chemotherapy alone for pleural mesothelioma (PM) (MARS2) reported "extended pleurectomy decortication was associated with worse survival to 2 years, and more serious adverse events for individuals with resectable PM, compared with chemotherapy alone." These results have led to considerable discourse regarding the future role of surgery for PM, and there has not been unanimity in the mesothelioma surgical community regarding the trial interpretation. This "perspective" evaluates MARS2 using internationally renowned PM experts who either agreed with the trial interpretation or who found issues with its conduct which may have influenced the results.
View Article and Find Full Text PDFDefensive Medicine in an Emergency Department: The Overuse of High-Sensitivity Cardiac Troponin I Testing.
Life (Basel)
November 2024
Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Eisenberg R&D Authority and Faculty of Medicine, The Hebrew University of Jerusalem, 12 Shmuel Beit Street, Jerusalem 9103102, Israel.
Introduction: Cardiac troponin I is routinely measured in patients with suspected acute coronary syndrome. However, when a high-sensitivity cardiac troponin I (hs-cTnI) test is ordered without a clear clinical indication, unexpectedly elevated levels can lead to unnecessary diagnostic workups and inappropriate management. This study aimed to investigate physicians' rationale for performing hs-cTnI tests in an emergency department (ED).
View Article and Find Full Text PDFEffect of splinting and kinesiotaping treatments on functional status, sleep quality and median nerve cross-sectional area in carpal tunnel syndrome: A single blind prospective randomized controlled study.
J Hand Ther
January 2025
Konya Beyhekim Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Konya, Turkey.
Background: The effect of conservative treatments on sleep quality in carpal tunnel syndrome is unclear.
Purpose: Comparing the effect of splinting and kinesiotaping in carpal tunnel syndrome on functional status, pain, grip strength, nerve cross-sectional area and sleep quality.
Study Design: Randomized controlled study.
Validation of AI-driven measurements for hip morphology assessment.
Eur J Radiol
December 2024
Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, MA, USA.
Rationale And Objectives: Accurate assessment of hip morphology is crucial for the diagnosis and management of hip pathologies. Traditional manual measurements are prone to mistakes and inter- and intra-reader variability. Artificial intelligence (AI) could mitigate such issues by providing accurate and reproducible measurements.
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