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Recent Advancements in Drug Targeting for Ferroptosis as an Antitumor Therapy: Development of Novel therapeutics.
Curr Cancer Drug Targets
January 2025
Department of Chemistry, Siddhachalam Laboratory, Raipur, 493221, Chhattisgarh, India.
Objectives: The primary objective of this review is to provide updated mechanisms that regulate ferroptosis sensitivity in cancer cells and recent advancements in drug targeting for ferroptosis as an antitumor therapy.
Methods: To achieve these objectives, a comprehensive literature review was conducted, analyzing recent studies on ferroptosis, including its cellular, molecular, and gene-level characteristics. The review involved an evaluation of advancements in ferroptosis drug research across various medical domains, with particular attention to novel therapeutic approaches in nano-medicine, TCM, and Western medicine.
The Efficacy of Repetitive Transorbital Alternating Current Stimulation (rtACS) in Patients With Optic Nerve Damage: A Systematic Review and Meta-Analysis.
Cureus
December 2024
Department of Ophthalmology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, SAU.
Optic nerve disorders significantly contribute to visual impairment with irreversible visual deficits. Current treatments have limited efficacy in resolving chronic visual deficits, necessitating novel therapeutic strategies. Neurorehabilitation techniques, including repetitive transorbital alternating current stimulation (rtACS), have emerged as promising approaches to restore lost visual function through the ability to modulate brain activity.
View Article and Find Full Text PDFEffects of coupled application of magnetoelectric activated water and amendments on photosynthetic physiological characteristics and yield of maize in arid regions.
Front Plant Sci
January 2025
State Key Laboratory of Eco-hydraulics in Northwest Arid Region, Xi'an University of Technology, Xi'an, China.
Seeking effective improvement agent control measures to enhance the photosynthetic physiological traits and yield levels of spring maize is crucial for efficient green agriculture in arid regions. Therefore, this study was conducted to clarify the effects of coupling improvement agents under magnetoelectric activated water irrigation conditions on the photosynthetic physiological traits, grain nutrients, and yield of spring maize in the arid region of northwest China. Field experiments were set up with three concentrations of growth regulators: 400 times (G1), 500 times (G2), and 600 times (G3), and three amounts of : 15 kg/ha (R1), 45 kg/ha (R2), and 75 kg/ha (R3), along with a control group CK, making a total of 10 treatments applied in the field experiment.
View Article and Find Full Text PDFA comparison of the persuasiveness of human and ChatGPT generated pro-vaccine messages for HPV.
Front Public Health
January 2025
CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Introduction: Public health messaging is crucial for promoting beneficial health outcomes, and the latest advancements in artificial intelligence offer new opportunities in this field. This study aimed to evaluate the effectiveness of ChatGPT-4 in generating pro-vaccine messages on different topics for Human Papillomavirus (HPV) vaccination.
Methods: In this study ( = 60), we examined the persuasive effect of pro-vaccine messages generated by GPT-4 and humans, which were constructed based on 17 factors impacting HPV vaccination.
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