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Antimicrobial spectrum against wound pathogens and cytotoxicity of star-arranged poly-l-lysine-based antimicrobial peptide polymers.
J Med Microbiol
September 2024
Department of Clinical Microbiology, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.
Article Synopsis
- - The text discusses the urgent need for new topical antimicrobials to manage wound infections as infection risks rise, emphasizing the lack of solid research on the cytotoxicity and effectiveness of antimicrobial peptides (AMPs) in current literature.
- - The study focuses on a specific AMP polymer called 16-PLL, investigating its bactericidal activity against ESKAPE pathogens and its cytotoxic effects on human cells, finding it effective but also toxic at certain concentrations.
- - Modifications to 16-PLL were made to reduce toxicity, but these did not significantly improve its safety profiles, indicating that while further development may be necessary, prioritizing the safety and selectivity of such antimicrobials is crucial for future research.
Star wars against leukemia: attacking the clones.
Leukemia
November 2024
Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Leukemia, although most likely starts as a monoclonal genetic/epigenetic anomaly, is a polyclonal disease at manifestation. This polyclonal nature results from ongoing evolutionary changes in the genome/epigenome of leukemia cells to promote their survival and proliferation advantages. We discuss here how genetic and/or epigenetic aberrations alter intracellular microenvironment in individual leukemia clones and how extracellular microenvironment selects the best fitted clones.
View Article and Find Full Text PDFSynthesis of star-shaped poly(lactide)s, poly(valerolactone)s and poly(caprolactone)s ROP catalyzed by N-donor tin(ii) cations and comparison of their wetting properties with linear analogues.
RSC Adv
July 2024
Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice Studentská 573 53210 Pardubice Czech Republic.
Article Synopsis
- The study explores the use of N-coordinated tin(ii) cations as catalysts for ring-opening polymerization (ROP) to produce well-defined linear poly(ε-caprolactone) (PCL) and poly(δ-valerolactone) (PVL).
- These catalysts also enable the synthesis of star-shaped polymers with varying functionalities, which were analyzed for their structural properties using SEC-MALS-Visco.
- To enhance hydrophobicity, new stannaboroxines were tested, showing potential improvements in the water resistance of the resulting polymers.
"All Women of Nagoya are Beautiful": Travel Records of a Korean Diplomat in 1764.
J Craniofac Surg
April 2024
Department of Plastic Surgery, Daejeon Eulji Medical Center, Eulji University, Daejeon.
The aim of this study is to ascertain how women of that era looked to a Korean diplomat who visited Japan in the 18th century. During 1763-1764, the "Documents on Joseon Tongsinsa (diplomatic mission)" contain 10 records of Korea and 2 records of Japan. Among them, "The Song of a Grand Trip to Japan" (), a Joseon gasa, was reviewed.
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