AI Article Synopsis
- Researchers created chimeric molecules combining insulin and Insulin-like Growth Factor-I (IGF-I) using enzymatic methods.
- The growth-promoting effects of these molecules were tested on a mouse mammary tumor cell line and compared with IGF-I, insulin, and a specific insulin peptide (DOI).
- Findings showed that while these chimeric molecules have lower activity than IGF-I and effects like insulin, they are more potent in promoting cell growth than DOI, highlighting the significance of a specific insulin chain in growth promotion.
Article Abstract
The chimeric molecules of "Insulin-Insulin-like Growth Factor-I", Ins/IGFI(8) and Ins/IGF-I(11) were obtained by means of enzymatic semisynthesis. The growth promoting activity of these chimeric molecules were evaluated with a mouse mammary tumor derived cell line, GR2H6, and compared with that of IGF-I, insulin and desoctapeptide insulin (DOI). Both compounds have lower activities than IGF-I and effects similar to insulin, but are more potent mitogens than DOI. These results indicate that the C-terminus of insulin B-chain is importantly involved in its growth promoting activities.
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