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Assessment of Bioactivity of Homalomena aromatica Essential Oil From Northeast India Through Combinative In Vitro and In Silico Approaches.
Chem Biodivers
November 2024
Agro-Technology and Rural Development Division, CSIR-North East Institute of Science and Technology (NEIST), Jorhat, Assam, India.
Homalomena aromatica Schott is a valuable medicinal aromatic plant having wide range of applications in ethnobotany, pharmacology, perfumery and flavor industry. Traditionally, various part of H. aromatica such as leaves and rhizomes were applied to treat joint pain, skin diseases, colds, asthma, diarrhea, and jaundice.
View Article and Find Full Text PDFDevelopmental nicotine exposure alters cardiovascular structure and function in neonatal and juvenile rats.
Am J Physiol Heart Circ Physiol
December 2024
Department of Physiology, College of Medicine, The University of Arizona, Tucson, Arizona, United States.
Article Synopsis
- Continuous nicotine exposure during pre- and postnatal development affects cardiovascular structure and function in neonatal and juvenile rats, with significant changes observed mainly in females.
- Echocardiography findings indicated that while both male and female DNE rats demonstrated altered heart function (like lower end-systolic volume and increased ejection fraction), females showed reduced left ventricular size metrics.
- The study suggests that developmental nicotine exposure may enhance the heart muscle's tension-generating ability, which could lead to issues like reduced cardiac reserve and increased oxidative stress, potentially impacting long-term cardiovascular health differently in males and females.
PD-1 Inhibitors Combined with Chemotherapy versus Re-irradiation/chemoradiotherapy for Unresectable Locally Recurrent T3-4 Nasopharyngeal Carcinoma: A Retrospective Study.
J Cancer
August 2024
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
To evaluate the efficacy, toxicity, and long-term outcomes of PD1 inhibitors plus chemotherapy versus re-irradiation/chemoradiotherapy in patients with unresectable locally recurrent T3-4 nasopharyngeal carcinoma (NPC). A retrospective analysis was conducted on 42 patients with recurrent nasopharyngeal cancer (NPC) after receiving immunochemotherapy or re-irradiation between February 2018 and May 2022 in Zhejiang Cancer Hospital. Overall survival (OS), progression-free survival (PFS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) were determined using the Kaplan-Meier method, log-rank test, and Cox proportional hazard regression.
View Article and Find Full Text PDFArsenic Poisoning-Induced Sensorineural Hearing Loss: A Case Report.
J Int Adv Otol
March 2024
Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Jining Medical College, Jining, China.
Arsenic is frequently used in alternative medicine, and it is critical to promptly identify and treat suspected arsenic toxicity in patients. In a case study, a female patient presented with several symptoms, including nausea, vomiting, bilateral tinnitus, hearing loss, vertigo, and other associated complaints. After admission, the patient showed lethargy, and topical application of Chinese herbal medicine was found on her left breast, along with visible pigmentation on her torso.
View Article and Find Full Text PDFA human-specific cytotoxic neopeptide generated by the deafness gene Cingulin.
J Genet Genomics
November 2024
MOE Key Laboratory of Model Animal for Disease Study, Department of Otolaryngology Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), The Affiliated Drum Tower Hospital of Medical School, Model Animal Research Center of Medical School, Nanjing University, Nanjing, Jiangsu 210061, China; Jiangsu Key Laboratory of Molecular Medicine and National Resource Center for Mutant Mice of China, Nanjing University, Nanjing, Jiangsu 210061, China; Research Institute of Otolaryngology, No. 321 Zhongshan Road, Nanjing, Jiangsu 210061, China. Electronic address:
Accumulation of mutant proteins in cells can induce proteinopathies and cause functional damage to organs. Recently, the Cingulin (CGN) protein has been shown to maintain the morphology of cuticular plates of inner ear hair cells and a frameshift mutation in CGN causes autosomal dominant non-syndromic hearing loss. Here, we find that the mutant CGN proteins form insoluble aggregates which accumulate intracellularly and lead to cell death.
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