AI Article Synopsis
- - The study aimed to evaluate how a polypeptide from Chlamys farreri (PCF) protects hairless mice skin from UV damage.
- - Various biochemical methods were used to assess enzyme levels, malondialdehyde (MDA) content, and the expression of specific proteins, while skin structure was examined under an electron microscope.
- - Results indicated that PCF boosts antioxidant activity, reduces MDA levels, enhances Bcl-2 protein expression, and maintains skin structure, demonstrating its protective effects against UV-induced skin damage.
Article Abstract
Aim: To study the protective effect of the polypeptide isolated from Chlamys farreri (PCF) on hairless mice skin damaged by ultraviolet A.
Methods: Enzymes and malondialdehyde (MDA) were determined by biochemical methods; the expressions of Bcl-2 protein and NOS protein were examined by immunohistochemical technique. The ultra-structure of the skin was observed through electronic microscope.
Results: PCF could enhance the activities of glutathione peroxidase (GSH-px), superoxide dismutase (SOD), and total anti-oxidative capacity (T-AOC). Also PCF could reduce the amount of MDA, increase the expression of Bcl-2 protein, and inhibit the expression of NOS protein. The ultra-structure of epidermis and fibroblasts remained normal in 20 % PCF groups; there were vacuoles in smooth endoplasm reticulum in epidermis of mice and the number of rough endoplasm reticulum in fibroblasts was decreased in model group.
Conclusion: PCF had the protective effects on hairless mice skin damaged by ultraviolet A via its anti-oxidative mechanisms.
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