AI Article Synopsis
- Fourteen South American medicinal plants were evaluated for their ability to inhibit HIV using ethanolic and aqueous extracts, revealing varying degrees of effectiveness.
- The aqueous extract from Baccharis trinervis showed significant anti-HIV activity without being toxic to human lymphocytic MT-2 cells.
- Further research on the active extract's antiviral properties led to a separation scheme aimed at isolating specific inhibitors of the virus.
Article Abstract
Ethanolic and aqueous extracts of 14 South American medicinal plants were tested for inhibitory activity on human immunodeficiency virus (HIV). Both extracts were relatively non-toxic to human lymphocytic MT-2 cells, but only the aqueous extract of Baccharis trinervis exhibited potent anti-HIV activity in an in vitro MTT assay. To delineate the extract-sensitive phase, some studies of the antiviral properties of the active extract are described in this paper. Based on the results presented here, a separation scheme was devised, which permitted the preliminary fractionation of the extract, with the aim of finding an inhibitor of this virus.
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| http://dx.doi.org/10.1248/bpb.25.1147 | DOI Listing |
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