AI Article Synopsis
- APCs can either promote immune responses or induce tolerance in the body.
- A specific subset of human APCs that express the enzyme indoleamine 2,3-dioxygenase (IDO) has been identified, which inhibits T cell growth in lab settings.
- This IDO-positive APC subset is marked by the presence of CD123 and CCR6, and it includes both mature and immature dendritic cells, indicating that they may play a regulatory role in human immune responses.
Article Abstract
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.
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| http://dx.doi.org/10.1126/science.1073514 | DOI Listing |
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