The purpose of this study was to evaluate the sedative-anaesthetic effects of a combination of medetomidine (M, 50 microg per pigeon), butorphanol (B, 50 microg per pigeon) and ketamine (K, 25 mg per pigeon) in domestic pigeons. Eight domestic pigeons (four male and four female, 8-15 months old) were used. The combination of Medetomidine and butorphanol injectable solutions were used to produce sedation. Ten minutes after M + B administration, K was injected. The anaesthetic effects of the drugs were reversed by administration of Atipamazole (AT) at 60 min after K administration. All drugs were injected into the pectoral muscles. The sedative-anaesthetic effects of the M + B-K combination and, alterations in respiratory rate (RR), heart rate (HR), electrocardiographic (ECG) findings and cloacal temperature (CT) were investigated before and 10 min after pre-medication with M + B, at 5, 15, 30, 45 and 60 min during the onset of K anaesthesia and at 1, 5, 10, 20, 30 and 60 min following the administration of AT. The HR and RR of pigeons decreased within 10 min following M + B administration and remained lower until 1st and 5 min of AT injection, respectively. In ECG, no significant alterations in P, Q, R and S-values were observed, however, arhythmia was recorded for three pigeons, which returned to normal values following AT administration throughout the measurement. Cloacal temperature decreased gradually during the anaesthesia from 41.0 to 32.7 degrees C. The drug combination used in this study produced a satisfactory general anaesthesia for seven of the eight pigeons. All pigeons were unconscious within 5 min after K administration as indicated by disappearance of the palpebral and corneal reflexes and lack of reaction to the pain stimuli during the study. The effect of AT administration was observed within 10 min as all pigeons responded partly against stimuli and all reflexes. It is concluded that M + B-K anaesthesia in pigeons is a safe and reliable anaesthetic protocol for surgery.
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http://dx.doi.org/10.1046/j.1439-0442.2002.00451.x | DOI Listing |
Arch Dermatol Res
January 2025
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia.
Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by dry skin, severe itching, redness, and inflammation. Its complex etiology, involving genetic, immunological, and environmental factors, necessitates innovative therapeutic approaches. This study investigates nanostructured lipid carriers (NLCs) formulated with traditional fermented coconut (Cocos nucifera L.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmacology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
Stress is linked to oxidative imbalance, neuroendocrine system malfunction, and cognitive dysfunction. It is a recognized cause of neuropsychiatric diseases. Natural flavonoid apigenin (API) has neuroprotective and antidepressant properties, but little is known about its potential in restoring memory function under stress-related circumstances.
View Article and Find Full Text PDFExplor Res Clin Soc Pharm
March 2025
University of Houston College of Pharmacy, Health 2, 4349 Martin Luther King Blvd, Houston, TX 77204, United States.
Background: The hospital at home (HaH) model has become more prevalent in the American healthcare system due to its ability to decrease acute care costs and readmission risk. Recent publications have provided guidance on optimizing medication management and patient safety by leveraging clinical pharmacy services. There is limited data on pharmacoeconomic impact of HaH implementation, specifically in underinsured patients.
View Article and Find Full Text PDFClin Cardiol
January 2025
Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, Sfax, Tunisia.
Background: Endothelial function (EndFx) is a core component of cardiovascular (CV) health and cardioprotection following acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI).
Hypothesis: AMI patients experience endothelial dysfunction (EndDys), associated with traditional CV risk factors and sleep patterns. EndFx may also predict short and mid-term outcomes.
J Cardiothorac Surg
January 2025
Department of Surgery, Division of Cardiac Surgery, Jefferson-Einstein Medical Center Philadelphia, Philadelphia, PA, USA.
Background: End-Stage Renal Disease (ESRD) is an independent risk factor in outcomes for traditional coronary artery bypass grafting (TRAD-CAB) utilizing aortic cross-clamping and cardioplegic arrest. In order to determine if Beating-Heart CABG (BH-CABG) techniques offer benefit in patients with ESRD, an analysis of the Society of Thoracic Surgeons (STS) predicted risk versus the actual outcomes was performed.
Methods: Between March 2017 - October 2023, all ESRD patients underwent BH-CABG by a single surgeon at a single institution.
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