The authors present their experience in surgical and combined treatment of juvenile angiofibroma of the base of the skull (JABS). A total of 180 children were treated, 93.8% of them had advanced tumor and were operated through external approach by Moore. Computed and MR tomographies were made preoperatively and postoperatively in all the patients. Benefits and drawbacks of the above tomographies are analysed. A technique of spiral computed contrast tomography in JABS is described. This tomography has the following advantages: volume visualization of the studied area without artefacts induced by movements; sharper visualization of the vessels; possibility of retrospective reconstruction of the sections with varying interval after the end of the procedure; improved quality of multi-plane reconstructions; reduced radiation dose and time of exposure.
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J Med Internet Res
January 2025
Department of Internal Medicine, Hospital Clinic, Institut d'Investigacio Biomèdica August Pi i Sunyer, Barcelona, Spain.
Background: Enhancing self-management in health care through digital tools is a promising strategy to empower patients with type 2 diabetes (T2D) to improve self-care.
Objective: This study evaluates whether the Greenhabit (mobile health [mHealth]) behavioral treatment enhances T2D outcomes compared with standard care.
Methods: A 12-week, parallel, single-blind randomized controlled trial was conducted with 123 participants (62/123, 50%, female; mean age 58.
Sci Adv
January 2025
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Designing binders to target undruggable proteins presents a formidable challenge in drug discovery. In this work, we provide an algorithmic framework to design short, target-binding linear peptides, requiring only the amino acid sequence of the target protein. To do this, we propose a process to generate naturalistic peptide candidates through Gaussian perturbation of the peptidic latent space of the ESM-2 protein language model and subsequently screen these novel sequences for target-selective interaction activity via a contrastive language-image pretraining (CLIP)-based contrastive learning architecture.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Computer Science, University of Exeter, Exeter, United Kingdom.
Community, core-periphery, disassortative and other node partitions allow us to understand the organisation and function of large networks. In this work we study common meso-scale structures using the idea of block modularity. We find that the configuration model imposes strong restrictions on core-periphery and related structures in directed and undirected networks.
View Article and Find Full Text PDFNeuroinformatics
January 2025
Translational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Blood flow velocity in the cerebral perforating arteries can be quantified in a two-dimensional plane with phase contrast magnetic imaging (2D PC-MRI). The velocity pulsatility index (PI) can inform on the stiffness of these perforating arteries, which is related to several cerebrovascular diseases. Currently, there is no open-source analysis tool for 2D PC-MRI data from these small vessels, impeding the usage of these measurements.
View Article and Find Full Text PDFEur Radiol
January 2025
Department of Radiology, Geneva University Hospitals, Geneva, Switzerland.
Objectives: Evaluating the impact of an AI-based automated cardiac MRI (CMR) planning software on procedure errors and scan times compared to manual planning alone.
Material And Methods: Consecutive patients undergoing non-stress CMR were prospectively enrolled at a single center (August 2023-February 2024) and randomized into manual, or automated scan execution using prototype software. Patients with pacemakers, targeted indications, or inability to consent were excluded.
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