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A High Fat, High Sugar Diet Exacerbates Persistent Post-Surgical Pain and Modifies the Brain-Microbiota-Gut Axis in Adolescent Rats.
Neuroimage
January 2025
Department of Neuroscience, Monash University, Melbourne, VIC, Australia; Gastroenterology, Immunology, Neuroscience (GIN) Discovery Program. Electronic address:
Persistent post-surgical pain (PPSP) occurs in a proportion of patients following surgical interventions. Research suggests that specific microbiome components are important for brain development and function, with recent studies demonstrating that chronic pain results in changes to the microbiome. Consumption of a high fat, high sugar (HFHS) diet can drastically alter composition of the microbiome and is a modifiable risk factor for many neuroinflammatory conditions.
View Article and Find Full Text PDFVaccination coverage and its determinants in patients with multiple sclerosis-a multicenter cross-sectional study.
Ther Adv Neurol Disord
January 2025
Department of Neurology, Jena University Hospital, Am Klinikum 1, Jena 07747, Germany.
Background: Complete vaccination coverage is recommended by multiple sclerosis (MS) societies for patients with multiple sclerosis (pwMS) to mitigate infection risks associated with disease-modifying therapies (DMTs).
Objectives: To analyze vaccination coverage and its determinants in pwMS compared to healthy controls, considering vaccination hesitancy, MS-specific vaccination beliefs, trust in information sources, and the role of general practitioners (GPs).
Methods: This cross-sectional multicenter observational study was conducted in six German MS centers.
Dilemma: Utilizing the activation decision-construction-action theory to understand and predict children's hypothetical decisions to conceal cases of school bullying.
Acta Psychol (Amst)
January 2025
Department of Educational and Counseling Psychology, McGill University, Canada.
The Decision component of the Activation-Decision-Construction-Action theory (ADCAT) proposes that if people perceive the benefits of lying higher than the truth, they are more likely to lie. To expand on the existing ADCAT research, the current study investigated the cost-benefit appraisals of 115 children ages 7-to-14 when concealing information about school bullying. Further, the current study examined the impact of the type of bullying (verbal vs.
View Article and Find Full Text PDFComparative Sensitivity of MRI Indices for Myelin Assessment in Spinal Cord Regions.
Tomography
January 2025
Laboratory for Biomarker Imaging Science, Graduate School of Biomedical Science and Engineering, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-8638, Japan.
Although multiple magnetic resonance imaging (MRI) indices are known to be sensitive to the noninvasive assessment of myelin integrity, their relative sensitivities have not been directly compared. This study aimed to identify the most sensitive MRI index for characterizing myelin composition in the spinal cord's gray matter (GM) and white matter (WM). MRI was performed on a deer's ex vivo cervical spinal cord.
View Article and Find Full Text PDFEarly subacute frontal callosal microstructure and language outcomes after stroke.
Brain Commun
January 2025
Queensland Aphasia Research Centre, University of Queensland, Brisbane 4029, Australia.
The integrity of the frontal segment of the corpus callosum, forceps minor, is particularly susceptible to age-related degradation and has been associated with cognitive outcomes in both healthy and pathological ageing. The predictive relevance of forceps minor integrity in relation to cognitive outcomes following a stroke remains unexplored. Our goal was to evaluate whether the heterogeneity of forceps minor integrity, assessed early after stroke onset (2-6 weeks), contributes to explaining variance in longitudinal outcomes in post-stroke aphasia.
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