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ARHGAP25: a novel player in the Pathomechanism of allergic contact hypersensitivity.
Front Immunol
March 2025
Semmelweis University, Department of Physiology, Budapest, Hungary.
Objective: Contact hypersensitivity (CHS), or allergic contact dermatitis (ACD), is an inflammatory skin disorder characterized by an exaggerated allergic reaction to specific haptens. During this delayed-type allergic reaction, the first contact with the allergen initiates the sensitization phase, forming memory T cells. Upon repeated contact with the hapten, the elicitation phase develops, activating mostly macrophages, cytotoxic T cells, and neutrophilic granulocytes.
View Article and Find Full Text PDFBiomarkers to aid in diagnosis of allergic contact dermatitis.
Front Allergy
February 2025
Department of Pathology, Microbiology, & Immunology, New York Medical College, Valhalla, NY, United States.
Allergic contact dermatitis (ACD) is an increasingly common skin condition characterized by itchy rashes in response to allergens. The most common diagnostic test involves patch testing (PT), but despite the efficacy of PT for identifying and guiding patients toward avoidance of allergens, PT alone does not elucidate the underlying biomechanistic changes which may be useful for sub-categorizing ACD further. In addition, some patients may never be able to identify their causative allergens unless they go to highly specialized ACD centers.
View Article and Find Full Text PDFExploring new horizons in allergic contact dermatitis treatment: the role of emerging therapies.
Actas Dermosifiliogr
March 2025
Contact Eczema and Immunoallergic Diseases Department. Dermatology, Spain; Dermatology Department. Hospital Universitario San Cecilio, Granada. Spain; Instituto de Investigación Biosanitaria ibs, Granada, Spain. Electronic address:
The resistant and recalcitrant nature of severe allergic contact dermatitis (ACD) makes treatment challenging. With advances in the understanding of the cellular and molecular pathogenesis of this dermatosis, new therapeutic options are emerging. In particular, the use of biologic drugs such as dupilumab and small molecule inhibitors, such as JAK inhibitors have gained momentum given the cross-cutting inhibition of multiple cytokine actions.
View Article and Find Full Text PDFApplications of heavy metal-based nanoparticles in cosmetics: a comprehensive review.
Cutan Ocul Toxicol
March 2025
Department of Physics, University of Sahiwal, Sahiwal, Pakistan.
The utilisation of heavy metal-based nanoparticles in cosmetic products has been steadily increasing because of their extraordinary physicochemical properties and benefits. In this thorough review, we will delve into the various types of nanoparticles, such as green nanoparticles, metallic nanoparticles, and carbon-based nanoparticles, with a special focus on heavy metal-based nanoparticles. These heavy metal-based nanoparticles exhibit exceptional physical and mechanical properties, making them suitable materials for cosmetic and personal care products.
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