Objectives: The purpose of this study was the development of the quality of life (QOL) questionnaire for dementia (QOL-D) in Japan.
Methods: We performed a questionnaire survey of QOL assessment in elderly patients with dementia in Japan, and developed QOL-D.
Results: The final version consists of only 31 items grouped into six response sets, each with its own scale. Reliability is good to excellent, and validity is, to some extent, established. The six domains of health-related QOL are divided into two groups. One is the positive and the other is the negative aspects of health-related QOL. The positive aspects have been shown to correlate positively with cognitive function and activities of daily living (ADL) score, whereas the negative aspects have not. The concept of QOL for elderly patients with dementia in Japan is similar to that in Western countries.
Conclusion: We demonstrated that QOL-D is a reliable and valid instrument for QOL assessment in elderly patients with dementia in Japan.
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http://dx.doi.org/10.1002/gps.711 | DOI Listing |
J Chin Med Assoc
January 2025
Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel disease caused by mutations in the NOTCH3 gene. This review highlights the increasing recognition of intracerebral hemorrhage (ICH) as a significant manifestation of CADASIL, often predominantly characterized by ischemic strokes and vascular dementia. Recent studies indicate that the prevalence of ICH in CADASIL patients ranges from 0.
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January 2025
Department of Community Building for Well-being, Center for Preventive Medical Sciences, Chiba University, Chiba-shi, Chiba, Japan.
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J Alzheimers Dis
January 2025
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.
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J Prev Alzheimers Dis
January 2025
Department of Neurology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan. Electronic address:
Plasma amyloid-β (Aβ) markers are significant predictors of Aβ pathology. However, their prognostic value for cognition in patients with Alzheimer's disease (AD) is unknown. We compared plasma amyloid-β precursor protein (APP) and Aβ levels between cognitively unimpaired participants (CU) and those with MCI due to AD and AD dementia.
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Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy.
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