Edema formation is a major problem in large ischemic infarcts, and the underlying breakdown of the blood-brain barrier is only incompletely understood. Here, we report that the tissue kallikrein-kinin system, which influences the permeability of the blood-brain barrier, is activated in stroke. In 22 patients with large infarcts in the territory of the middle cerebral artery, we found elevated plasma concentrations of the tissue kinin kallidin. The data suggest that further studies on a possible role of kinin receptor antagonists on edema after stroke are warranted.
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Article Synopsis
- Tissue kallikrein (TK) might help protect the brain during a stroke, but we don't know the best time to use it yet.
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- Giving TK during a stroke activates certain pathways in the body that help reduce damage caused by the stroke, which suggests it might be really helpful in treating stroke if used at the right time.
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