The complex hydroelectrolytic problem is examined by a study of the physiology and physiopathology of fluids, electrolytes and proteins. A number of interesting critical and clinical problems of use in the pre- and postoperative treatment of surgical patients and in cases where a change in the hydroelectric balance takes place, are involved. Therapy is facilitated if needs are calculated on the basis of the three basic principles: 1) daily physiological need; 2) replacement of physiological losses; 3) elimination of the existing deficiency.
Download full-text PDF |
Source |
---|
Blood
May 2001
Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Center, Duarte, CA 91010, USA.
In prior studies, it was demonstrated that the redox metabolism of doxorubicin leads to the formation of promutagenic oxidized DNA bases in human chromatin, suggesting a potential mechanism for doxorubicin-related second malignancies. To determine whether a similar type of DNA damage is produced in the clinic, peripheral blood mononuclear cell DNA from 15 women treated with infusional doxorubicin (165 mg/m(2)) as a single agent was examined for 14 modified bases by gas chromatography/mass spectrometry with selected ion monitoring. Prior to the 96-hour doxorubicin infusion, 13 different oxidized bases were present in all DNA samples examined.
View Article and Find Full Text PDFMinerva Chir
May 1999
Dipartimento di Discipline Chirurgiche e Anatomiche, Università degli Studi, Palermo.
Aim: The authors evaluate the value of hepatic intrarterial chemotherapy (HAC) as an alternative treatment for hepatic metastases from colo-rectum cancer unsuited to radical surgery.
Methods: This study evaluates the physiopathological and pharmacodynamic bases for this type of treatment, the correct procedure for patient staging and selection, the surgical technique used to insert the infusional system, surgical complications and those linked to endoarterial treatment, the evaluation of response and the results. Complications correlated to the infusional system were evaluated in a total of 1223 patients in 10 non-randomised studies and 7 randomised studies taken from the literature.
Clin Exp Pharmacol Physiol
November 1998
Department of Medical Oncology, Royal Melbourne Hospital, Victoria, Australia.
1. Painstaking progress in drug development is well illustrated by 5-fluorouracil (5FU), originally designed 40 years ago as a fluorinated analogue of the naturally occurring base uracil. Innovative pharmacokinetic and pharmacodynamic strategies have seen significant clinical improvements for cancer patients over the past decade.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
September 1998
London Regional Cancer Center, University of Western Ontario, Canada.
Background And Purpose: To determine the percentage of complete responders and the resectability rate for patients with locally advanced carcinoma of the rectum treated by 5-fluorouracil (5-FU) infusional chemotherapy and pelvic radiation.
Materials And Methods: Between October 1992 and June 1996, 29 patients with a diagnosis of locally advanced unresectable rectal cancer received preoperative 5 FU by continuous intravenous infusion at a dose of 225 mg/m2/day concurrent with pelvic radiation (median 54 Gy/28 fractions). All patients were clinical stage T4 on the bases of organ invasion or tumor fixation.
The complex hydroelectrolytic problem is examined by a study of the physiology and physiopathology of fluids, electrolytes and proteins. A number of interesting critical and clinical problems of use in the pre- and postoperative treatment of surgical patients and in cases where a change in the hydroelectric balance takes place, are involved. Therapy is facilitated if needs are calculated on the basis of the three basic principles: 1) daily physiological need; 2) replacement of physiological losses; 3) elimination of the existing deficiency.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!