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Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine-induced seizures.
Brain Behav
February 2021
Laboratory of the Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Introduction: Local anesthetics are widely used in clinical practice. While toxicity is rare, these drugs can cause potentially lethal seizures.
Objective: In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs.
Lidocaine-Induced Cardiac Arrest in the Emergency Department: Effectiveness of Lipid Therapy.
J Emerg Med
January 2016
Department of Emergency Medicine, New Jersey Medical School, Newark, New Jersey.
Background: Local anesthetics are commonly used in the emergency department (ED). Overdoses can lead to disastrous complications including cardiac toxicity and arrest. Recognition of local anesthetic systemic toxicity (LAST) is important; however, prevention is even more critical.
View Article and Find Full Text PDFRecurrent seizures after lidocaine ingestion.
J Adv Pharm Technol Res
February 2015
Department of Emergency, Mazandaran University of Medical Sciences, Sari, Iran.
Lidocaine has a concentration-dependent effect on seizures. Concentrations above 15 μg/mL frequently result in seizures in laboratory animals and human. We report a case of central nervous system (CNS) lidocaine toxicity and recurrent seizure after erroneous ingestion of lidocaine solution.
View Article and Find Full Text PDFEmulsified isoflurane increases convulsive thresholds of lidocaine and produces neural protection after convulsion in rats.
Anesth Analg
February 2014
From the Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University; Department of Anesthesiology, West China Second Hospital of Sichuan University; and Department of Anesthesiology, Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.
Background: Local anesthetic-induced convulsions remain a concern of anesthesiologists when performing regional anesthesia. Our previous study found that the lidocaine requirement for IV regional anesthesia was reduced with coadministration of emulsified isoflurane. We designed this study to examine whether emulsified isoflurane could increase the convulsive threshold of lidocaine and produce protection after a lidocaine-induced convulsion.
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