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Long-Term Sequential Digital Dermoscopy of Low-Risk Patients May Not Improve Early Diagnosis of Melanoma Compared to Periodical Handheld Dermoscopy.
Cancers (Basel)
February 2023
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, 4, 20072 Pieve Emanuele, Italy.
Sequential digital dermoscopy (SDD) enables the diagnosis of a subgroup of slow-growing melanomas that lack suspicious features at baseline examination but exhibit detectable change on follow-up. The combined use of total-body photography and SDD is recommended in high-risk subjects by current guidelines. To establish the usefulness of SDD for low-risk individuals, we conducted a retrospective study using electronic medical records of low-risk patients with a histopathological diagnosis of cutaneous melanoma between 1 January 2016 and 31 December 2019, who had been referred and monitored for long-term follow-up of clinically suspicious melanocytic nevi.
View Article and Find Full Text PDFAnalysis of dermoscopic changes of blue nevi on digital follow-up: A 21-year retrospective cohort study.
J Eur Acad Dermatol Venereol
May 2023
Department of Dermatology, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.
Background: Blue nevi are benign dermal melanocytic proliferations that are often easy to recognize clinically. Rarely, these lesions can display atypical features, suggesting the presence of a malignant blue nevus or mimicking cutaneous metastases of melanoma.
Objective: To describe the clinical evolution of blue nevi over time and to assess the need for monitoring these lesions.
Effects of Growth Hormone (GH) Supplementation on Dermatoscopic Evolution of Pigmentary Lesions in Children with Growth Hormone Deficiency (GHD).
J Clin Med
January 2022
Department of Dermatology, University "G D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
Recent reports have confirmed higher levels of growth hormone (GH) receptor (GHR) transcripts in malignant melanomas (MM), yet the role of GH in the pathogenesis of MM remains controversial. Although melanocytes appear to be hormonally responsive, the effects of GH on MM cells are less clear. A direct correlation between GH administration and the development of melanoma seems possible.
View Article and Find Full Text PDFAssessment of nail findings in children with atopic dermatitis.
Clin Exp Dermatol
December 2021
Department of Dermatology, Firat University Hospital, Elazig, Turkey.
Background: Cutaneous findings are well known in atopic dermatitis (AD), but nail changes have not received as much attention.
Aim: To determine the clinical and disease-related capillaroscopic findings of nail findings in paediatric patients with AD.
Methods: In total, 100 participants aged 2-16 years were sourced from the dermatology outpatient clinic: 50 of these had been diagnosed with AD according to the Hanifin-Rajka criteria, and the others were 50 healthy controls (HCs) without AD.
Measurement of Sub-femtomolar Concentrations of Prostate-Specific Antigen through Single-Molecule Counting with an Upconversion-Linked Immunosorbent Assay.
Anal Chem
August 2019
Institute of Analytical Chemistry, Chemo- and Biosensors , University of Regensburg, 93053 Regensburg , Germany.
Single-molecule (digital) immunoassays provide the ability to detect much lower protein concentrations than conventional immunoassays. As photon-upconversion nanoparticles (UCNPs) can be detected without optical background interference, they are excellent labels for so-called single-molecule upconversion-linked immunosorbent assays (ULISAs). We have introduced a UCNP label design based on streptavidin-PEG-neridronate and a two-step detection scheme involving a biotinylated antibody that efficiently reduces nonspecific binding on microtiter plates.
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