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Background: Major Depressive Disorder (MDD) is the most common psychiatric disorder with high prevalence and disease burden. Biological treatments of MDD over the last several decades include a wide range of antidepressants and neurostimulation therapies. While recent meta-analyses have explored the efficacy and tolerability of antidepressants, the changing trends of biological treatments have not been evaluated.

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Interventions to treat premature ejaculation: a systematic review short report.

Health Technol Assess

March 2015

School of Health and Related Research (ScHARR) Technology Assessment Group, The University of Sheffield, Sheffield, UK.

Background: Premature ejaculation (PE) is commonly defined as ejaculation with minimal sexual stimulation before, on or shortly after penetration and before the person wishes it. PE can be either lifelong and present since first sexual experiences (primary), or acquired (secondary), beginning later (Godpodinoff ML. Premature ejaculation: clinical subgroups and etiology.

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Pharmacological interventions for self-injurious behaviour in adults with intellectual disabilities: Abridged republication of a Cochrane systematic review.

J Psychopharmacol

July 2014

Black Country Partnership NHS Foundation Trust, Psychiatry of Intellectual Disability, Wolverhampton, UK.

We aimed to determine clinical effectiveness of pharmacological interventions for self-injurious behaviour in adults with intellectual disability. We searched the following databases: CENTRAL; MEDLINE; EMBASE; PsycINFO; CINAHL; SCI; SSCI; Conference Proceedings Citation Index - Science; Conference Proceedings Citation Index - Social Science and Humanities; ZETOC; World Cat .We also searched ClinicalTrials.

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Pharmacological interventions for self-injurious behaviour in adults with intellectual disabilities.

Cochrane Database Syst Rev

April 2013

Psychiatry of Intellectual Disability, Southern Health NHS Foundation Trust, Oxford, UK.

Background: Self-injurious behaviour among people with intellectual disability is relatively common and often persistent. Self-injurious behaviour continues to present a challenge to clinicians. It remains poorly understood and difficult to ameliorate despite advances in neurobiology and psychological therapies.

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Obsessive compulsive disorder (OCD) is a condition with a prevalence of around 1-2% (3-4% in some studies) with a recognised protocol for its treatment produced by the national institute for health and clinical excellence (NICE). NICE recommends that all patients with OCD are first offered treatment with cognitive behavioural therapy (CBT) concentrating on exposure and response prevention (ERP) before proceeding to selective serotonin re-uptake inhibitors (SSRIs). Treatment may later be augmented with clomipramine and/or an antipsychotic.

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