AI Article Synopsis
- - The text discusses the creation and effectiveness of new sordarin oxazepine derivatives through specific chemical processes.
- - A major step in the synthesis involved selectively oxidizing a triol followed by a process called double reductive amination to produce closed-ring compounds.
- - These new compounds have demonstrated antifungal properties, particularly effective against fungi such as Candida albicans, Candida glabrata, and Cryptococcus neoformans.
Article Abstract
The synthesis and biological activity of sordarin oxazepine derivatives are described. The key step features a regioselective oxidation of an unprotected triol followed by double reductive amination to afford the ring-closed products. The spectrum of antifungal activity for these novel derivatives includes coverage of Candida albicans, Candida glabrata, and Cryptococcus neoformans.
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| http://dx.doi.org/10.1016/s0960-894x(02)00529-2 | DOI Listing |
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