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N-terminomics profiling of host proteins targeted by excretory-secretory proteases of the nematode Angiostrongylus vasorum identifies points of interaction with canine coagulation and complement cascade.
PLoS One
January 2025
Institute of Parasitology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
The cardiopulmonary nematode Angiostrongylus vasorum can cause severe disease in dogs, including coagulopathies manifesting with bleeding. We analysed A. vasorum excretory/secretory protein (ESP)-treated dog plasma and serum by N-terminome analysis using Terminal Amine Isotopic Labelling of Substrates (TAILS) to identify cleaved host substrates.
View Article and Find Full Text PDFComparison of Bacterial Intracellular and Secreted Proteins produced in Milk Versus Medium for Escherichia coli by Proteomic Analysis.
J Dairy Sci
January 2025
College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, Shandong, China; Bathurst Future Agri-Tech Institute, Qingdao Agricultural University, Qingdao, 266109, Shandong, China. Electronic address:
The growth and reproduction of microorganisms are dependent on nutrient supply. Here, Milk and LB media were utilized as nutrition sources for Escherichia coli, and the changes in bacterial and secretory proteins at 3 time points (3, 9, and 18 h) in the growth cycle were studied using a label-free proteomics technique. The findings revealed that the abundances of bacterial intracellular proteins inosine/xanthosine triphosphatase and universal stress protein F increase dramatically during the growth phase in milk and LB media.
View Article and Find Full Text PDFEffect of Fold-Promoting Mutation and Signal Peptide Screening on Recombinant Glucan 1,4-Alpha-maltohydrolase Secretion in Pichia pastoris.
Appl Biochem Biotechnol
January 2025
College of Life Science and Technology, Wuhan Polytechnic University, Wuhan, 430023, China.
Glucan 1,4-alpha-maltohydrolase (3.2.1.
View Article and Find Full Text PDFTranscriptional responses to macrocyclic lactone exposure in larvae using RNA-seq.
bioRxiv
December 2024
Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS.
, the causative agent of zoonotic toxocariasis in humans, is a parasitic roundworm of canids with a complex lifecycle. While macrocyclic lactones (MLs) are successful at treating adult infections when used at FDA-approved doses in dogs, they fail to kill somatic third-stage larvae. In this study, we profiled the transcriptome of third-stage larvae derived from larvated eggs and treated with 10 μM of the MLs - ivermectin and moxidectin with Illumina sequencing.
View Article and Find Full Text PDFA cell atlas of the human fallopian tube throughout the menstrual cycle and menopause.
Nat Commun
January 2025
Center for Research Informatics, The University of Chicago, Chicago, IL, USA.
The fallopian tube undergoes extensive molecular changes during the menstrual cycle and menopause. We use single-cell RNA and ATAC sequencing to construct a comprehensive cell atlas of healthy human fallopian tubes during the menstrual cycle and menopause. Our scRNA-seq comparison of 85,107 pre- and 46,111 post-menopausal fallopian tube cells reveals substantial shifts in cell type frequencies, gene expression, transcription factor activity, and cell-to-cell communications during menopause and menstrual cycle.
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