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Maintained homeostasis: LGYD facilitated the restoration of ISCs following radiation exposure by activating Hes1.
Phytomedicine
April 2025
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, PR China; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, PR China; State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, PR China. Electronic address:
Background: Radiation-induced Intestinal Injury (RIII) affects quality of life in radiotherapy patients; Liangxue Guyuan Yishen Decoction (LGYD) offers protection but requires further study on its mechanism.
Purpose: The aim of this study was to investigate the heterogeneity of cellular responses in the intestine at a single-cell level following radiation and LGYD treatment.
Study Design: This study's design includes in vivo and in vitro assessments to evaluate LGYD's effects on intestinal cells post-radiation, targeting survival, recovery, and molecular pathways.
Oral colon-retentive inulin gels protect against radiation-induced hematopoietic and gastrointestinal injury by improving gut homeostasis.
Int J Biol Macromol
March 2025
Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address:
Ionizing radiation-induced injury often occurs in nuclear accidents or large-dose radiotherapy, leading to acute radiation syndromes characterized by hematopoietic and gastrointestinal injuries even to death. However, current radioprotective drugs are only used in hospitals with unavoidable side effects. Here, we heated the aqueous solution of inulin, a polysaccharide dietary fiber, forming colon-retentive gel as a radiation protector in radiotherapy.
View Article and Find Full Text PDFAlterations in Gut Microbiota Correlate With Hematological Injuries Induced by Radiation in Beagles.
Int J Microbiol
December 2024
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Fengtai, Beijing 100071, China.
Dynamics of gut microbiota and their associations with the corresponding hematological injuries postradiation remain to be elucidated. Using single whole-body exposure to Co- ray radiation at the sublethal dose of 2.5 Gy, we developed a beagle model of acute radiation syndrome (ARS) and then monitored the longitudinal changes of gut microbiome and hematology for 45 days.
View Article and Find Full Text PDF[Reconstructive procedures in women with irradiation injuries of urinary tract: change of a paradigm].
Urologiia
May 2024
Russian Medical Academy of Continuous Professional Education, Department of Urology and Surgical Andrology, Moscow, Russia.
Introduction: Radiation therapy is one of the main methods of treating pelvic malignant tumors, which provides good oncological results. Specific features of the pelvic anatomy may result in various radiation injuries of adjacent organs, which are complicated by genitourinary fistulas, post-radiation fibrosis with the formation of hydronephrosis, microcyst, reducing the quality of life.
Aim: To describe the relevance and importance of the correct choice of surgical treatment in patients with post-radiation urinary tract injuries.
Gastrointestinal tract organoids as novel tools in drug discovery.
Front Pharmacol
August 2024
School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Article Synopsis
- Organoids are advanced models that replicate the structure and function of organs, initially developed from the small intestine, and now include various other organs like the liver and lungs.
- This review highlights the lack of comprehensive research on gastrointestinal tract (GIT) organoids, emphasizing their role in studying diseases such as inflammatory bowel disease and drug screening for treatments.
- GIT organoids have proven valuable in testing drug effects, understanding viral infections like Norovirus and SARS-CoV-2, assessing compound toxicity, and exploring immune responses and microbiome interactions, while also introducing cost-effective culture methods.
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