Variable Response Inconsistency (M-VRIN) and True Response Inconsistency (M-TRIN) scales were developed for the Millon Adolescent Clinical Inventory using 104 male and 78 female delinquents, ages 13-17 years. M-VRIN efficacy was assessed by comparing nonrandom protocols of 76 male and 34 female delinquents, ages 13-17 years, with 100 computer-generated random protocols. Nonrandom protocols were screened using a matched-pair Minnesota Multiphasic Personality Inventory-Adolescent or Jesness Inventory. M-TRIN efficacy was assessed by comparing protocols with 160 simulated acquiescent and nonacquiescent protocols. Specificities of .95 or higher showed sensitivities up to .89 for M-VRIN, and .90 and .79 for M-TRIN. Predictive power and overall effectiveness are reported for several base rates. Small relationships may exist between M-VRIN and race, and between M-TRIN and gender.
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http://dx.doi.org/10.1037//1040-3590.14.3.320 | DOI Listing |
Sci Rep
January 2025
Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.
A key question about social media use is whether it constitutes an addiction. A possible frame of reference to investigate this question is the Incentive Sensitizations Theory (IST), as it provides a solid empirical background to understand the motivational and hedonic aspects of problematic behaviors. A central assumption of IST that addiction-related cues play a pivotal role in addictive behaviors has remained relatively understudied in the context of social media use.
View Article and Find Full Text PDFJMIR Med Inform
January 2025
Department of Systems Design Engineering, Faculty of Engineering, University of Waterloo, Waterloo, ON, Canada.
Background: While expert optometrists tend to rely on a deep understanding of the disease and intuitive pattern recognition, those with less experience may depend more on extensive data, comparisons, and external guidance. Understanding these variations is important for developing artificial intelligence (AI) systems that can effectively support optometrists with varying degrees of experience and minimize decision inconsistencies.
Objective: The main objective of this study is to identify and analyze the variations in diagnostic decision-making approaches between novice and expert optometrists.
Drug Deliv Transl Res
January 2025
Kinimmune, Inc. St. Louis, 63141, Missouri, USA.
PD-L1/PD-1 checkpoint inhibitors (CPIs) are mainstream agents for cancer immunotherapy, but the prognosis is unsatisfactory in solid tumor patients lacking preexisting T-cell reactivity. Adjunct therapy strategies including the intratumoral administration of immunostimulants aim to address this limitation. CpG oligodeoxynucleotides (ODNs), TLR9 agonists that can potentiate adaptive immunity, have been widely investigated to tackle PD-L1/PD-1 resistance, but clinical success has been hindered by inconsistent efficacy and immune-related toxicities caused by systemic exposure.
View Article and Find Full Text PDFFront Immunol
January 2025
Guangdong Immune Cell Therapy Engineering and Technology Research Center, Center for Protein and Cell-based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Chimeric antigen receptor T-cell (CAR-T) therapies have shown promise in glioblastoma clinical studies, but responses remain inconsistent due to heterogeneous tumor antigen expression and immune evasion post-treatment. NKG2D CAR-T cells have demonstrated a favorable safety profile in patients with hematologic tumors, and showed robust antitumor efficacy in various xenograft models, including glioblastoma. However, malignant glioma cells evade immunological surveillance by reducing NKG2D ligands expression or cleavage.
View Article and Find Full Text PDFLife Metab
June 2024
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Atherosclerosis is the major contributor to cardiovascular mortality worldwide. Alternate day fasting (ADF) has gained growing attention due to its metabolic benefits. However, the effects of ADF on atherosclerotic plaque formation remain inconsistent and controversial in atherosclerotic animal models.
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