AI Article Synopsis
- Na(x) is a sodium channel found in the brain's circumventricular organs, playing a key role in maintaining sodium balance in body fluids.
- In various visceral organs, such as the lung, heart, and kidney, non-myelinating Schwann cells in peripheral nerves exhibit high levels of Na(x) expression.
- Additionally, in the lung, Na(x) is present in alveolar type II cells, suggesting its involvement in regulating local extracellular sodium levels through sodium absorption.
Article Abstract
Na(x) is an extracellular sodium-level-sensitive sodium channel expressed in the circumventricular organs in the brain, essential loci for the sodium-level homeostasis in body fluids. Here, we examined the localization of Na(x) throughout the visceral organs at the cellular level. In visceral organs including lung, heart, intestine, bladder, kidney and tongue, a subset of Schwann cells within the peripheral nerve trunks were highly positive for Na(x). An electron microscopic study indicated that these Na(x)-positive cells were non-myelinating Schwann cells. In the lung, Na(x)-positive signals were also observed in the alveolar type II cells, which actively absorb sodium and water to aid gas exchange through the alveolar surface. It was thus suggested that the Na(x) sodium channel is involved in controlling the local extracellular sodium level through sodium absorption activity.
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| http://dx.doi.org/10.1016/s0304-3940(02)00708-5 | DOI Listing |
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