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Targeting PCSK9, through an innovative cVLP-based vaccine, enhanced the therapeutic activity of a cVLP-HER2 vaccine in a preclinical model of HER2-positive mammary carcinoma.
J Transl Med
January 2025
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Background: HER2-targeted therapies have revolutionized the treatment of HER2-positive breast cancer patients, leading to significant improvements in tumor response rates and survival. However, resistance and incomplete response remain considerable challenges. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is a novel therapeutic strategy for the management of dyslipidemia by enhancing the clearance of low-density lipoprotein cholesterol receptors, however recent evidence also shows links between PCSK9 and cancer cells.
View Article and Find Full Text PDFRe-architecture for requirements of academic space development in the universities: design and validitation of RASD questionnaire.
Sci Rep
January 2025
Department of Leadership and Educational management, Faculty of Psychology and Educational Sciences, Shahid Beheshti University, Tehran, Iran.
Universities are the cornerstone of social development and progress; however, it is essential to enhance the academic environment to support this mission. The objective of this research is to identify the Requirements for Academic Space Development (RASD) in universities. The present study was conducted in 2022-2023 using a mixed-method with a qualitative-quantitative sequence.
View Article and Find Full Text PDFCurrent airway management practice among Swiss anesthesiologists : Results of a national survey.
Anaesthesiologie
January 2025
Department of Anaesthesia, Spital Grabs, 9472, Grabs, Switzerland.
Background: While limited data on the impact of implementing guidelines in airway management on outcomes exist, there is a consensus that the implementation and the adherence to guidelines enhance patient safety. Recently, the Swiss Society for Anesthesiology and Perioperative Medicine (SSAPM) endorsed the guidelines of The Fondation Latine des Voies Aériennes (FLAVA) as the official guidelines for airway management in Switzerland. This study aimed to determine current practice of airway management in Switzerland.
View Article and Find Full Text PDFDisease continuum centered on Parkinson's disease.
Eur Neuropsychopharmacol
January 2025
Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, China; Academy of Military Medical Sciences, 27 Taiping Road, Beijing 100850, China. Electronic address:
Parkinson's disease (PD), once viewed as a neurodegenerative disorder, is now increasingly recognized as part of a broader disease continuum, intricately linked to comorbidities across various organ systems. This study provides a snapshot of the disease continuum centered on PD, using a disease-wide association study (DWAS) involving 392,423 individuals-including 4,235 PD cases. This DWAS identifies disease clusters of PD comorbidities across the musculoskeletal, circulatory, digestive, and respiratory systems.
View Article and Find Full Text PDFLong-Term Follow-Up of Ultrasound-Guided Glossopharyngeal Nerve Block Treatment for Glossopharyngeal Neuralgia: A Retrospective Clinical Study of 43 Cases [Letter].
J Pain Res
January 2025
Department of Ophthalmology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, 434000,People's Republic of China.
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