The author places Grmek's editorial within the flux of the historiographical debate which, since the middle of the 1970s, has concentrated on two major crises due to the end of social science-oriented 'scientific history' and to the 'linguistic turn'. He also argues that Grmek's historiographical work of the 1980s and 1990s was to some extent an alternative to certain observed changes in historical fashion and has achieved greater intelligibility because of its commitment to a rational vision of science and historiography.
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J Agric Food Chem
January 2025
State Key Laboratory of Synthetic Biology, School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Jinnan District, Tianjin 300350, China.
Ursolic acid, a plant-derived pentacyclic triterpenoid with anti-inflammatory, antioxidant, and other bioactive properties, holds significant potential for use in nutritional supplements and drug development. However, its extraction from medicinal plants is inefficient due to low yield and dependence on seasonality and geography. Herein, we use modular metabolic engineering to enhance ursolic acid production in by dividing the biosynthetic pathway into five modules.
View Article and Find Full Text PDFFront Med (Lausanne)
January 2025
Department of Integrated Traditional Chinese Medicine (TCM) and Western Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Introduction: Recurrent spontaneous abortion (RSA) represents a significant clinical challenge, with its underlying mechanisms yet to be fully elucidated. Despite advances in understanding, the precise pathophysiology driving RSA remains unclear. Angelica sinensis, a traditional herbal remedy, is frequently used as an adjunctive treatment for miscarriage.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Institute for Theoretical Physics, Georg-August University of Göttingen, 37077 Göttingen, Germany.
A Single-Chain-in-Mean-Field (SCMF) algorithm was introduced to study block copolymer electrolytes in nonequilibrium conditions. This method self-consistently combines a particle-based description of the polymer with a generalized diffusion equation for the ionic fluxes, thus exploiting the time scale separation between fast ion motion and the slow polymer relaxation and self-assembly. We apply this computational method to study ion fluxes in electrochemical cells containing poly(ethylene oxide)-polystyrene (PEO-PS) block copolymers with added lithium salt.
View Article and Find Full Text PDFActa Pharmacol Sin
January 2025
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.
Ovarian cancer presents a significant treatment challenge due to its insidious nature and high malignancy. As autophagy is a vital cellular process for maintaining homeostasis, targeting the autophagic pathway has emerged as an avenue for cancer therapy. In the present study, we identify apolipoprotein B100 (ApoB100), a key modulator of lipid metabolism, as a potential prognostic biomarker of ovarian cancer.
View Article and Find Full Text PDFMetabolism
January 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, PR China. Electronic address:
Aims: Osteoclast energy metabolism is a promising target for treating diseases characterized by high osteoclast activity, such as osteoporosis. However, the regulatory factors involved in osteoclast bioenergetic processes are still in the early stages of being fully understood. This study reveals the effects of follicle-stimulating hormone (FSH) on osteoclast energy metabolism.
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