Objective: To investigate the nasal absorption regularities of psoralen and isopsoralen of different concentrations.
Method: Building an experimental model of rat in situ nasal recirculation and determining the contents of psoralen and isopsoralen by HPLC.
Result: The nasal absorption of psoralen and isopsoralen fitted in with zero order kinetics, getting saturated with the increase of concentration.
Conclusion: A suitable concentration is necessary for the preparation of nasal remedies psoralen and isopsoralen.
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