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Phthalates toxicity to rats, mice, birds, and fish: A thematic scoping review.
Heliyon
January 2025
Department of Statistics, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
Background: Phthalates, a large group of endocrine disruptors, are ubiquitous in the environment and detrimental to human health. This scoping review aimed to summarize the effects of phthalates on laboratory animals relevant to humans, assess toxicity, and analyze mechanisms of toxicity for public health concerns.
Methods: Articles were retrieved from Google Scholar, PubMed, ScienceDirect, and Web of Science search engines.
Role of salvianolic acid B in the treatment of acute ischemic stroke: a systematic review and meta-analysis of animal models.
Front Pharmacol
December 2024
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Background: Salvianolic acid B (Sal B) is potentially the most valuable water-soluble active component in Salvia miltiorrhiza. Its chemical formula contains multiple phenolic hydroxyl groups, so it has a strong antioxidant capacity.
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Robinin protects chondrocytes injury via TLR2/TLR4/NF-κB signaling in osteoarthritis.
Cell Biochem Biophys
December 2024
Department of Orthopedics, Affiliated Hospital of Hubei University of Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei Provincial Institute of Traditional Chinese Medicine, Wuhan, China.
Osteoarthritis (OA) is a joint disease closely related to aging and characterized by degeneration of articular cartilage. Robinin is a natural agent with various pharmacological properties. Recently, Robinin has been found to have the potential to improve the bone-related diseases.
View Article and Find Full Text PDFPioglitazone Modulates Microglia M1/M2 Polarization Through PPAR-γ Pathway and Exerts Neuroprotective Effects in Experimental Subarachnoid Hemorrhage.
Mol Neurobiol
December 2024
Department of Neurosurgery, The Affiliated Yixing Hospital of Jiangsu University, Jiangsu Province, Yixing, 214200, China.
Subarachnoid hemorrhage (SAH), a subtype of hemorrhagic stroke primarily resulting from the rupture of intracranial aneurysms, remains a significant contributor to disability and mortality, notwithstanding advancements in treatment. This study investigates the neuroprotective effects of pioglitazone in SAH, focusing on the PPAR-γ pathway and its potential role in mitigating early brain injury (EBI) following SAH. Neuroprotective efficacy was assessed through neurobehavioral assessment, brain water content analysis, TUNEL, immunofluorescence, western blotting, and inflammatory factor assay.
View Article and Find Full Text PDFApoc1 Knockdown Alleviates High Glucose-induced Oxidative Stress and Apoptosis of Renal Tubular Cells by Binding to Clusterin.
Cell Biochem Biophys
December 2024
Department of Nephrology & Rheumatology, Chongqing University Shapingba Hospital, People's Hospital of Shapingba District, Chongqing, 400030, China.
Article Synopsis
- Diabetic nephropathy (DN) is a severe complication of diabetes that involves damage to renal tubules, with increased levels of apolipoprotein C1 (Apoc1) in patients' serum.
- This study investigates the molecular mechanisms behind high glucose-induced damage in kidney cells using a DN mouse model and human kidney cells, analyzing the roles of Apoc1 and Clusterin.
- Results indicate that Apoc1 levels rise while Clusterin levels fall in DN, and knocking down Apoc1 reduces oxidative stress and cell death; Apoc1 also interacts with Clusterin, suggesting that targeting the Apoc1/Clusterin pathway could be therapeutic for DN.
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