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Impact of disease cyclicity on quality-of-life impairment-A mixed method explanatory study.
JAAD Int
February 2025
Division of Dermatology, Department of Medicine, National University Healthcare System, Singapore.
Background: Disease cyclicity, a composite measure of unpredictable and daily fluctuations of symptoms, strongly predicts quality-of-life (QoL) impairment.
Objective: To explore the mechanisms by which cyclicity impacts QoL.
Methods: 1:1 semi-structured interviews were conducted and qualitatively analyzed using grounded theory.
Discordance, accuracy and reproducibility study of pathologists' diagnosis of melanoma and melanocytic tumors.
Nat Commun
January 2025
Digital Biomarkers for Oncology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Accurate melanoma diagnosis is crucial for patient outcomes and reliability of AI diagnostic tools. We assess interrater variability among eight expert pathologists reviewing histopathological images and clinical metadata of 792 melanoma-suspicious lesions prospectively collected at eight German hospitals. Moreover, we provide access to the largest panel-validated dataset featuring dermoscopic and histopathological images with metadata.
View Article and Find Full Text PDFPatient views on continued immune checkpoint inhibition following progression in advanced melanoma: A qualitative study.
Bull Cancer
January 2025
Palliative Care Unit, ULR 2694 METRICS, CHU de Lille, Université de Lille, 59000 Lille, France.
Introduction: Immune checkpoint inhibition has revolutionized the management of metastatic melanoma, including in the final stages of disease progression: because it is well tolerated, some teams do not discontinue it in hopes of slowing disease progression. The risks are that treatment may be continued unnecessarily, causing side effects, and reduce access to specialist palliative care, in addition to increasing the cost of treatment.
Method: We explored the experiences of 10 patients in a university hospital with metastatic melanoma under continued immune checkpoint inhibitors combined with specialist palliative care.
What's Eating You? Hookworm and Cutaneous Larva Migrans.
Cutis
November 2024
Dr. Bloomquist is from the School of Medicine, University of South Carolina, Columbia. Dr. Elston is from the Department of Dermatology & Dermatologic Surgery, Medical University of South Carolina, Charleston.
Hookworm infection represents a major global disease burden, in terms of both morbidity and economic impact, and there has been a resurgence of hookworms in developed nations where these parasites were once thought to be eradicated. Hookworms can infest humans or other mammals as their primary hosts depending on the species. The 2 most common species that seek human hosts-Necator americanus and Ancylostoma duodenale-enter the body through the epidermis, and hookworm infection may manifest as a pruritic and papular inflammatory reaction know as ground itch.
View Article and Find Full Text PDFThe physical, emotional, social, and functional dimensions of epidermolysis bullosa. An interview study on burdens and helpful aspects from a patients' perspective.
Orphanet J Rare Dis
January 2025
EB House Austria, Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, Salzburg, Austria.
Article Synopsis
- Epidermolysis bullosa (EB) is a painful genetic skin condition causing blisters even from light touch, significantly impacting the quality of life of those affected.
- The study aims to analyze the psychosocial effects of living with EB and identify coping mechanisms through semi-structured interviews with individuals across three countries.
- Results reveal various physical, emotional, social, and functional challenges faced by people with EB, emphasizing the need for personalized emotional support and understanding of individual experiences.
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