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Catheter-Directed Thrombolysis in the Management of Thrombotic Peripheral Artery Occlusions-Acute and Mid-Term Clinical Outcomes.
J Clin Med
September 2024
University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg, Südring 15, 79189 Bad Krozingen, Germany.
Article Synopsis
- The study assessed the safety and effectiveness of catheter-directed thrombolysis (CDT) using rt-PA in patients with symptomatic peripheral artery disease from January 2013 to December 2020.
- Of the 1238 patients treated, serious adverse events occurred in 41.3%, with bleeding being the most common complication at 25.4%, and notable rates of limb salvage at 91.6% and 88.8% after 12 and 24 months, respectively.
- Key predictors for complications included increasing age, the use of certain medications (abciximab and alprostadil), and the duration of the lysis treatment, highlighting a significant risk associated with CDT despite its high success rate.
Role of Intracoronary Adrenaline in the Treatment of No-Reflow Phenomenon in Patients Undergoing Percutaneous Coronary Intervention.
Cureus
May 2024
Cardiovascular Disease, University Hospital Center Mother Teresa, Tirana, ALB.
The no-reflow phenomenon is defined as the failure to restore coronary flow demonstrated by the reduced or missing flow in angiography despite the patent artery. There are pharmacological strategies proposed and studied to manage the no-reflow phenomenon. The medication groups used are purine nucleoside (adenosine), calcium channel blockers (verapamil, nicardipine), beta 2 receptor agonists (adrenaline, nitroprusside), fibrinolytic agents (streptokinase, tissue plasminogen activators), glycoprotein IIb/IIIa inhibitors (abciximab, tirofiban).
View Article and Find Full Text PDFQualitative classification of thrombus images as a way to improve quantitative analysis of thrombus formation in flow chamber assays.
PLoS One
March 2024
Department of Haemostatic Disorders, Medical University of Lodz, Lodz, Poland.
Background: Thrombus formation in vitro under flow conditions is one of the most widely used methods to study haemostasis and to evaluate the activity of potential antithrombotic compounds. Assessment of the results of these experiments is often based on a quantification of microscopic images of thrombi. In a majority of reported analysis all thrombi visualised in an image are quantified as one homogenous class.
View Article and Find Full Text PDFA novel technique to quantify the kinetics of blood clot contraction based on the expulsion of fluorescently labeled albumin into serum.
J Thromb Haemost
June 2024
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address:
Background: The platelet-driven contraction or retraction of blood clots has been utilized to obtain blood serum for laboratory studies, but now, in vitro clot contraction assays are used in research laboratories and clinics to assess platelet functionality. The static final extent of clot contraction measured using a clot size or expelled serum volume can be supplemented substantially with a dynamic analysis.
Objectives: To provide a step-by-step protocol for a relatively simple and affordable new automated methodology to follow the kinetics of blood clot contraction, which allows for simultaneous measurements of various samples at a time and requires only a fluorescence plate reader.
Adverse Drug Effect Profiles of Gp2b/3a Inhibitors: A Comparative Review of the Last Two Decades.
Cureus
November 2023
General Medicine, American University of Antigua College of Medicine, St John's, ATG.
ST-Elevation Myocardial Infarction and non-ST Elevation Myocardial Infarction belong to the acute coronary syndrome group of diseases. These conditions are characterized by the complete or partial blockage of one or several coronary arteries, resulting in myocardial injury or necrosis. Various medications are used in their treatment, with the most recent addition being Glycoprotein IIb/IIIa inhibitors.
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