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Modular cascade with engineered HpaB for efficient synthesis of hydroxytyrosol.
Bioorg Chem
January 2025
College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108 China; Institute of Enzyme Catalysis and Synthetic Biotechnology, Fuzhou University, Fuzhou 350108 China. Electronic address:
Hydroxytyrosol, a naturally occurring chemical with antioxidant and antiviral properties, is widely used in the nutrition, pharmaceutical, and cosmetic industries. In the present study, a modularized cascade composed of Modules 1 and 2 was designed and implemented to convert l-tyrosine to hydroxytyrosol. Module 1 was a four-enzymatic cascade for converting l-tyrosine to tyrosol.
View Article and Find Full Text PDFThe role of artificial intelligence in preoperative planning for Total Hip Arthroplasty: a systematic review.
Front Artif Intell
December 2024
Department of Orthopedic Hip and Knee Surgery, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Background: Total Hip Arthroplasty (THA) is a transformative surgical intervention for hip joint disorders, necessitating meticulous preoperative planning for optimal outcomes. With the emergence of Artificial Intelligence (AI), preoperative planning paradigms have evolved, leveraging AI algorithms for enhanced decision support and imaging analysis. This systematic review aims to comprehensively evaluate the role of AI in THA preoperative planning, synthesizing evidence from studies exploring various AI techniques and their applications.
View Article and Find Full Text PDFCAZymes ( C arbohydrate A ctive En Zymes ) degrade, synthesize, and modify all complex carbohydrates on Earth. CAZymes are extremely important to research in human health, nutrition, gut microbiome, bioenergy, plant disease, and global carbon recycling. Current CAZyme annotation tools are all based on sequence similarity.
View Article and Find Full Text PDFCitri reticulate pericranium-derived extracellular vesicles exert antioxidant and anti-inflammatory properties and enhance the bioactivity of nobiletin by forming EVs-nob nanoparticles.
Front Cell Dev Biol
December 2024
Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River (Ministry of Education), College of Horticulture and Landscape Architecture, Southwest University, Chongqing, China.
Plant-driven extracellular vesicles (PEVs) have attracted significant interest due to their natural origin, remarkable bioactivity, and efficacy in drug encapsulation and target delivery. In our work, extracellular vesicles from Citri Reticulate Pericranium (CEVs) were isolated and investigated their physicochemical characteristics and biological activities. We identified the vesicle structures as regular, with a particle size of approximately 200 nm.
View Article and Find Full Text PDFEmotional Eating Interventions for Adults Living With Overweight and Obesity: A Systematic Review and Meta-Analysis of Behaviour Change Techniques.
J Hum Nutr Diet
February 2025
School of Health, Obesity Institute, Leeds Beckett University, Leeds, UK.
Background: Emotional eating (EE) is a barrier to the long-term success of weight loss interventions. Psychological interventions targeting EE have been shown to reduce EE scores and weight (kg), though the mechanisms remain unclear. This review and meta-analysis aimed to identify the specific behaviour change techniques (BCTs) associated with improved outcomes.
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