[Effect of gui xin tong on sorbitol and nerve conduction velocity in diabetic rats].

Objective: To investigate the effect of Gui Xin Tong(GXT) on sorbitol and nerve conduction velocity in diabetic rats.

Method: The model rats suffering from diabetes were induced by STZ, and blood sugar levels above 16 mmol/L were chosen for observation. The rats were divided into GXT group, AG group and control group. The nerve conduction velocity, aldose reductase activity and sorbitol in STZ induced diabetic rats were investigated.

Result: Compared with the control group GXT could increase the sciatic nerve conduction velocity significantly (P < 0.05), decrease the RBC and sciatic nerve, aldose reductase activity, and RBC-sorbitol content.

Conclusion: GXT has the effect of improving nerve conduction velocity significantly and reducing aldose reductase activity and sorbitol