Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0092-8674(02)00902-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SUMO1 modification reduces oxidative stress and SUMO1ylated AKAP4 degradation affects frozen-thawed boar sperm quality.
Anim Reprod Sci
February 2025
Department of Animal Science, College of Agriculture, Yanbian University, Yanji, Jilin Province, China. Electronic address:
Low-temperature injury affects normal physiological function and viability of boar sperm during cryopreservation. Small ubiquitin-like modifier (SUMO) modification of proteins after translation is related to the cell stress response but the relationship between SUMO modification and oxidative stress in freeze-thawed sperm remains unclear. A-kinase ankyrin 4 (AKAP4) and its precursor proAKAP4 are two main proteins in mammalian sperm.
View Article and Find Full Text PDFVagal stimulation ameliorates murine colitis by regulating SUMOylation.
Sci Transl Med
November 2024
Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Inflammatory bowel diseases (IBDs) are chronic debilitating conditions without cure, the etiologies of which are unknown, that shorten the lifespans of 7 million patients worldwide by nearly 10%. Here, we found that decreased autonomic parasympathetic tone resulted in increased IBD susceptibility and mortality in mouse models of disease. Conversely, vagal stimulation restored neuromodulation and ameliorated colitis by inhibiting the posttranslational modification SUMOylation through a mechanism independent of the canonical interleukin-10/α7 nicotinic cholinergic vagal pathway.
View Article and Find Full Text PDFSUMOylation modification of HNRNPK at the K422 site promotes invasion in glioblastoma.
Int J Biol Sci
November 2024
Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, 250012, China.
Glioblastoma multiforme (GBM) is a highly heterogeneous brain tumor with limited treatment options. Recent studies revealed cellular heterogeneity and the potential for interconversion between distinct cell types on the basis of RNA sequencing and single-cell analyses. The ability of different cell types to adapt to their surrounding environment and undergo transformation significantly complicates the study and treatment of GBM.
View Article and Find Full Text PDFPorphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase-2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP-2.
Mol Oral Microbiol
October 2024
Department of Basic Medical Science, College of Medicine, University of Arizona, Phoenix, Arizona, USA.
Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases-2 (MMP-2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression. The periodontal pathogen Porphyromonas gingivalis is highly associated with the progression of periodontitis. GroEL protein of periodontal pathogens is an important virulence factor that can invade the body through either the bloodstream or digestive tract and is associated with numerous systemic diseases.
View Article and Find Full Text PDFSumoylation of thymine DNA glycosylase impairs productive binding to substrate sites in DNA.
J Biol Chem
November 2024
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA; Molecular and Structural Biology Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, USA. Electronic address:
Article Synopsis
- The enzyme thymine DNA glycosylase (TDG) plays a crucial role in correcting DNA mistakes and removing methyl groups from DNA, but its activity is reduced when modified by SUMO (small ubiquitin-like modifier).
- Research using kinetic experiments indicated that SUMOylation lowers TDG's ability to properly bind and repair various DNA mispairs, ultimately decreasing its effectiveness.
- A specific mutation in TDG’s SUMO interaction site can restore its glycosylase activity by improving its ability to bind to damaged DNA, suggesting that intramolecular interactions between SUMO and TDG can negatively impact its function.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!