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Modulation of Paracetamol-Induced Hepatotoxicity by Acute and Chronic Ethanol Consumption in Mice: A Study Pilot.
Toxics
November 2024
Laboratory of Metabolic Biochemistry, Institute of Exact and Biological Sciences, UFOP, Ouro Preto 35402-136, MG, Brazil.
Paracetamol (APAP) overdose is the leading cause of drug-induced liver injury, leading to acute liver failure. However, the role of concurrent acute or chronic ethanol ingestion in this context requires further clarification. In this study, we investigated the effects of acute and chronic ethanol ingestion on APAP-induced hepatotoxicity.
View Article and Find Full Text PDFCriminal legal penalties, substance use, and overdose: a concept mapping study examining Colorado's criminal legal penalties.
BMC Glob Public Health
January 2025
Division of General Internal Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, 80045 CO, USA.
Background: In the USA, many states, including Colorado, have increased criminal penalties for illicit opioid possession, which may alter overdose risk. We aimed to evaluate the relationship between Colorado's increased drug-related criminal legal penalties, risk of overdose, and substance use patterns.
Methods: We used concept mapping - a mixed-methods approach used to develop a conceptual understanding of an issue from a community lens - to engage with people with living and/or lived experience with the criminal legal system, substance use, and/or overdose, their loved ones, and service providers.
Description of implementing a mail-based overdose education and naloxone distribution program in community supervision settings during COVID-19.
J Subst Use Addict Treat
December 2024
Department of Pharmacy Practice & Science, Center for the Advancement of Pharmacy Practice, University of Kentucky, 789 S. Limestone, Lexington, KY 40508, USA. Electronic address:
Introduction: This study uses the Exploration, Preparation, Implementation, and Sustainment (EPIS) model to retrospectively describe the mail-based overdose education and naloxone distribution (OEND) program developed in collaboration with the Kentucky Department of Corrections (DOC) for use in the HEALing Communities Study in Kentucky (HCS-KY) and details the reach of this innovative delivery model.
Methods: HCS-KY is a community-engaged cluster-randomized trial assessing the effects of implementing evidence-based practices, including OEND, on overdose death reduction across 16 communities highly impacted by the opioid epidemic in Kentucky. The study launch coincided with the COVID-19 pandemic.
Trends in Sudden Cardiac Death Among Adults Aged 25 to 44 Years in the United States: An Analysis of 2 Large US Databases.
J Am Heart Assoc
December 2024
Division of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA.
Background: Sudden cardiac death (SCD) in early adults aged 25 to 44 years represents an important and unexpected cause of death. We assessed trends in SCD-related mortality in the United States from 1999 to 2020 among early adults to determine differences by sex, ethnoracial groups, urbanization, and census region.
Methods And Results: Mortality data were retrieved from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) data set from 1999 to 2020.
Using concept mapping methods to evaluate overdose data to action program efforts in Allegheny County, Pennsylvania.
Eval Program Plann
December 2024
Evaluation Institute, University of Pittsburgh School of Public Health, Department of Behavioral and Community Health Sciences, Pittsburgh, United States.
Background: The Pitt Public Health evaluation team used a mixed-methods, community-based participatory research method of concept mapping to evaluate factors affecting the Overdose Data to Action (OD2A) opioid overdose surveillance and prevention project outcomes for Allegheny County, Pennsylvania.
Methods: In June 2021 we developed the focal prompt: "What factors work to help or limit OD2A program outcomes at the individual, community, and or/system level?"Community partners participated in three phases: Brainstorming, Sorting and Rating, and Interpretation. Using concept mapping software, we applied multidimensional scaling to visualize a point map displaying factors and their relative relationships, and hierarchical cluster analysis to generate concept maps displaying clusters of factors.
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